DEPLETION OF OXYTETRACYCLINE FROM CHICKEN TISSUES
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 3
Abstract
Oxytetracycline residue was evaluated in broiler tissues after oral administration of the drug in drinking water. Thirty broiler chickens-4 weeks old age were administered Oxytetracycline in drinking water for five consecutive days at a dose of 200.0 mg/l. Six birds were sacrificed at day 1,3,5,7, and 10 from withdrawal of the drug. Tissue samples from muscle, liver and kidney were collected in plastic containers and stored at –20°C for analysis. The concentration of the drug in different tissues was evaluated using LC-MS/MS. The concentration of the drug in tissues after one day from withdrawal of treatment was121.0μg/Kg in the muscle, 207.0 μg/Kg in the liver and 97.6 μg/Kg in the kidney. From the results of this study in day 1 only the concentration in the muscle (121μg/Kg) was above MRL set by EU. On day 3 the concentration in all tissues was below EU MRL. This study indicates that withdrawal period of Oxytetracycline in broiler chickens could be 3 days, which is similar to that recommended by USFDA.
Authors and Affiliations
Abdelrahman Mostafa
Keywords
Related Articles
- EP ID EP620436
- DOI -
- Views 113
- Downloads 0
EARLY ADVERSE EVENTS OF PELVIC RADIOTHERAPY
radiotherapy is used with or without chemotherapy to treat malignancies in the pelvis that occur in gynecologic, genitourinary, and gastrointestinal organs. Radiation can cause functional effects on GIT organs including...
THE EFFECTIVENESS OF INTRAUTERINE BLOOD TRANSFUSION IN TREATING HDFN CAUSED BY RED BLOOD CELL ALLOIMMUNIZATION
Background: Hemolytic disease of fetus and newborn (HDFN) due to maternal red cell alloimmunization showed a wide propagation worldwide, causing the increase in rates of mortality and morbidity. Intrauterine transfusion...
CLINICAL ASPECT OF TEMPORAL REGION WSR TO SRUNGATAKA MARMA AS DESCRIBED IN INDIAN SYSTEM OF MEDICINE
From the time immemorial, they were keen in unravelling the secrets of this most sophisticated and complicated machinery. Ayurveda with a broad approach had explained the human body considering its various aspects- metap...
IMIPENEM RESISTANCE AMONG GRAM NEGATIVE BACILLI FROM GREAT KWA RIVER, NIGERIA
Emergence of antibiotics resistance bacteria is a persistent global problem affecting public health. The occurrence and widespread resistance to carbapenems among environmental bacterial isolates can constitute a major t...
THERAPEUTIC & PHARMACOLOGICAL POTENTIAL OF NIGELLA SATIVA LINN. IN UNANI SYSTEM OF MEDICINE: A REVIEW
The seed of Nigella sativa Linn. from family Ranunculaceae commonly known as kalonji or Shooneez are used in Unani system of medicine and other traditional medicine. The use of Nigella Sativa for the treatment of human i...