Derivatives Synthesis and Characterization of Some New α-Hydroxy-β-acetamido Substituted Tryptamine
Journal Title: International Journal of Research in Chemistry and Environment (IJRCE) - Year 2012, Vol 2, Issue 1
Abstract
Novel α-Hydroxy-β-acetamido substituted tryptamines were synthesized by the trimolecular condensation between N-Phthalimido-α-hydroxy acetaldehyde, Meldrum’s acid and various substituted indoles followed by aminolysis, and careful deprotection. N-Phthalimido-α-hydroxy acetaldehyde was prepared by the reaction between Phthalimide and Glyoxalic acid followed by direct reduction with hexamine in acetic acid medium.
Authors and Affiliations
Senthil S. , Fazal M. I.
Keywords
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