DESIGN AND CHARECTERISATION OF FLOATING TABLETS OF RANOLAZINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
The purpose of this research was to develop hydro dynamically balanced systems of Ranolazine, an anti-anginal drug which are designed to increase the gastric residence time, thus prolonging the drug release. In the present study, the tablets were prepared by direct compression technique using different polymers like HPMC (K4M, K15M, and K100M), Carbopol 934P, Chitosan and sodium bicarbonate as the gas generating agent. The prepared tablets were evaluated with different parameters like hardness, friability, uniformity of weight, content uniformity, in-vitro buoyancy studies, swelling characteristics and in-vitro dissolution study. The tablets containing Ranolazine released 75.19 to 99.44% of drug at the end of 12th hr by in-vitro release study. The formulation RF8 was selected as an optimized formulation because it gave the best result in terms of the required in-vitro buoyancy study, good floating integrity, drug release in sustained release manner and best fitted to Korsmeyer-Peppas model with R2 value of 0.983. As the n value for the Korsmeyer-Peppas model was found to be less than 0.89, it follows case-2 transport. In-vivo radiographic studies revealed that the tablets remain in the stomach for 300±10 mins which indicates the increase in the gastric residence time. Short-term stability studies indicated no appreciable changes in the drug content and In-vitro drug release rates of formulation RF8.
Authors and Affiliations
Krishnarajan Devarajan , Manivannan Rangasamy , Nidhin Chandroth , Senthilkumar Natesan
Keywords
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