PREPARATION AND IN-VITRO EVALUATION OF LIQUID SOLID COMPACTS OF GLIBENCLAMIDE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
The purpose of this study is to develop a novel liquid-solid technique to enhance the dissolution rate of poorly water solubledrug ofglibenclamide, which is a BCS class II drug. Liqui-solid system refers to the formulations that are formed by conversion of liquid drugs, drug suspensions or solution in non-volatile solvents into dry, non adherent, free flowing and compressible powder mixture. Hence the dissolution step, a pre-requisite for drug absorption, is by passed and better bioavailability of poorly soluble drug is achieved. Liquisolid tablets were prepared by using PEG -400 as non volatile liquid vehicles and Avicel PH 101,Aerosil as carrier and coating materials respectively. Alltheformulations were evaluated for disintegration time, hardness and friability time, wetting time, in-vitro dissolution study. Among all the formulation F3 &F9 were considered to be the best formulation, whichrelease up to 95% of the drug in 60 mints.
Authors and Affiliations
V. N. L. Sirisha, B. Sruthi, M. Eswaraiah
Keywords
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