Design and synthesis of two steroid derivatives from 2-nitroestrone and theoretical evaluation of their interaction with BRCA-1
Journal Title: Asian Journal of Green Chemistry - Year 2019, Vol 3, Issue 2
Abstract
Several compounds have been prepared to treatment of breast cancer; however, some of these drugs may produce some side effects. The aim of this study is to synthesize two new steroid derivatives (Compounds 7 or 8) to evaluate their theoretical interaction with a breast cancer protein (BRCA-1) using a docking model. The preparation of 7 and 8 was carried out using a series of reactions which involves; (i) addition/cyclization; (ii) amination, (iii) etherification and (iv) esterification. Chemical structure of the compounds was confirmed using elemental analysis and NMR spectrum. The following stage involved the theoretical evaluation on the interaction of both compounds 7 or 8 with BRCA-1 protein surface using a docking model. The results showed that compound 7 could bound to different type of amino acid residues of BRCA-1 protein compared with 8; this phenomenon, may exert changes in the biological activity of BRCA-1 protein. All data suggest that compound 7 or 8 could be an alternative therapeutic for treatment of the breast cancer.
Authors and Affiliations
Figueroa-Valverde Lauro, Diaz-Cedillo Francisco, Rosas-Nexticapa Marcela, Mateu-Armand Virginia, Montano-Tapia Elizabeth, Hau-Heredia Lenin, Lopez-Ramos Maria, García-Cervera Elodia, Pool-Gómez Eduardo, Cauich-Carrillo Regina, Alfonso-Jimenez Alondra, Cabrera-Tuz Jhaira
Keywords
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- EP ID EP468914
- DOI 10.22034/ajgc.2018.144189.1093
- Views 106
- Downloads 0
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