Imidazole mediated synthesis of spirooxindoles in water using isatin as a privileged scaffold
Journal Title: Asian Journal of Green Chemistry - Year 2019, Vol 3, Issue 0
Abstract
This work describes the synthesis of complex small molecules spirooxindoles using imidazole as an efficient organocatalyst. The three components coupling reactions of isatin, malononitrile and enolizable 4-hydroxycoumarin were performed in water as a green solvent. The reaction is done with imidazole an amphoteric organocatalyst to construct spiro-molecules in high yields. The significant features of this protocol are neutral reaction condition, readily available low cost catalyst, metal free, strong acid/base free, and reusable reaction medium with no column chromatography separation. This methodology is useful for the easy access of structurally complex, highly functionalized spirooxindole molecules with important medicinal chemistry applications.
Authors and Affiliations
Md. Nasim Khan, Digvijaysinh K. Parmar, Hardik B. Bhatt
Keywords
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- EP ID EP647218
- DOI 10.33945/SAMI/AJGC.2019.4.4
- Views 106
- Downloads 0
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