Determination of antibacterial activity of trheecyclic triazines against klebsiella pneumoniae
Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2016, Vol 29, Issue
Abstract
Introduction. Nowadays the important task for scientists is to intensify search for new compounds with antimicrobial activity of different chemical classes what can be used as a base for creating new antimicrobial drugs. The results suggest that a way to search the new perspective and approaches to the development of innovative synthetic drugs lies in the field of analysis of newly synthesized compounds.The goal of the work was to study antibacterial properties of substances of threecyclic triazines class compounds towards Klebsiella pneumoniae.Materials and methods. In this work it was used the substances of class of threecyclic triazines and Klebsiella pneumoniae pathogen. In the research disco-diffusion method and method of serial microdilution were used.Results of research and discussion. It was detected that threecyclic triazines had sufficient activity against Klebsiella pneumoniae. The most active among the tested substances were compounds ODI-44, ODI-45, ODI-46, ODI-48 and ODI-57 with MIC 0.0041 mg/cm3 and growth inhibition zone from 23±0.36 mm to 24.6±0.21 mm.Conclusion and prospects for further research:It was revealed that chemical compounds of treecyclic triazines showed antimicrobial activity against Klebsiella pneumoniae.The most promising compounds are ODI-44 (3-oxo-2,3-dihydro-1H-[1,2,4]triazino[5,6- b][1,4]benzothiazine-7-carboxylic acid), ODI-45 (7-methyl-3-oxo-2,3-dihydro-1H- [1,2,4]triazino[5,6-b][1,4]benzothiazine-9-carboxylic acid), ODI-46 (2,4-dioxo-1,3,4,5-tetrahydro- 2H-pyrimido[4,5-b][1,4]benzothiazine-7-carboxylic acid), ODI-48 (3-(dimethylamino)-2H- [1,2,4]triazino[6,5-b][1,4]benzothiazine-8-carboxylic acid) and ODI-57(7-methyl-3-oxo-N-[4- (trifluoromethyl)phenyl]-2,3-dihydro-1H-[1,2,4]triazino[5,6-b][1,4]benzothiazine-9-carboxamide) and they can be considered as a candidates for future research.
Authors and Affiliations
M. Babkina, Larisa Palchykovska, O. Vasylchenko, Oleksandr Tarasov
Keywords
Related Articles
- EP ID EP274215
- DOI -
- Views 142
- Downloads 0
Pseudo-allergic reactions to tuberculin in cattle
Introduction. Bovine tuberculosis (TB) is a chronic bacterial disease of cattle and other species of domestic and wild animals. Bovine TB can also infect humans. Delayed hypersensitivity test is the standard diagnostical...
Efficiency of the preparation on the basis of essential oils and oily solution of chlorophyllipt in the treatment of nipples hyperkeratosis of the udder of cows
Introduction. The market of veterinary preparations of Ukraine is represented by a large assortment of means for the treatment of udder nipples hyperkeratosis, but their composition does not differ significantly by activ...
Analysis of the epizootic situation on the rabies in Chernihiv oblast in 2017
Introduction. Here we report the results of monitoring of the epizootic situation on rabies in Chernihiv oblast in 2017, analysis of how it changed compared to the previous year. The goal of the work. To determine the ge...
Methodical approaches to the radial hemolysis reaction use for equine infectious anemia diagnostics
Introduction. Of Equine Infectious Anemia (EIA) is one of the most important issue that constantly registers in many countries with the developed horse breeding. Diagnostics of EІA is a basic element of the preventive me...
Immunohistochemistry of the organs of hemopoiesis and immunogenesis of chickens at infectious bronchitis
Introduction. Infectious bronchitis of birds recorded in all countries of the world and causes considerable economic losses in industrial and private poultry farms. One of the important problems in the poultry industry r...