Determination uncertainty of aluminum residues in human albumin using top-down evaluation
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 5
Abstract
Objective To evaluate the determination uncertainty of aluminum residues in human albumin by inductively coupled plasma mass spectrometry (ICP-MS). Methods The aluminum residues in human albumin was determined by ICP-MS, and the top-down method was applied to assess the reasons of uncertainty and calculate the uncertainty. Results The relative standard uncertainty of the aluminum content in human albumin at the three quality control levels was 0.54 ng/mL, 1.68 ng/mL and 4.54 ng/mL, respectively, which met the requirements of the guidelines for bioanalytical methods in the Chinese Pharmacopoeia(2020). Conclusion The top-down method is simple and quick to assess the uncertainty of aluminum residues in human albumin, and is suitable for the uncertainty assessment of analytical methods in biological laboratories.
Authors and Affiliations
Meiling ZHENG, Zhiming LI, Danfeng LI
Keywords
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- EP ID EP738547
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.05.011
- Views 33
- Downloads 0
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