DEVELOPMENT AND CHARACTERIZATION OF MANNOSYLATED QUERCETIN LOADED LIPOSOMES FOR SKIN CARCINOMA
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 10
Abstract
The solar UV radiation is the major trigger factor that causes skin cancer. Nearly 65% of cases of melanoma occurs dues to high exposure to the UV radiation. It also accounts for 90% of the nonmelanoma skin cancers also referred to as NMSC also including the cases of basal cell carcinoma (BCC) and the squamous cell carcinoma (SCC). The rate of malignancy in other cases has seemed to get reduced but this is not the situation in case of NMSC, which seemed to have increased and also affect people of younger ages. Cases of NMSC can be accounted for 15,000 deaths in the USA alone. This is surely one of the major health concerns of the nation also. In order to find a solution to this problem a new form of drug delivery system using the specific ligand that has receptor on the surface or the target cells is being proposed. The current discussion deals with the making of the mannosylated quercetin loaded liposomes that can be used for targeting cancerous cells. The methods of transmission electron microscopy (TEM) used for the surface morphology. The MTT assay was done against two different cell lines so that their cancer-preventive or curative properties can be assured. The research, hence establishes the fruitful development of Mannosylated Quercetin loaded liposomes (MA-QuLps) for the targeting of the skin cancer cells.
Authors and Affiliations
S. Saraf et al.
Keywords
Related Articles
- EP ID EP656924
- DOI 10.13040/IJPSR.0975-8232.10(10).4753-59
- Views 90
- Downloads 0
SYNTHESIS OF NEFOPAM ANALOGUES AND CHARACTERISATION
Modified Benzoxazocine moiety of Nefopam with N-Protected-ethanolamine, fluorobenzene benzylbromide, 2,3-dimethyl-benzene, naphthalene, fluro-naphthalene. In these modification Friedel Craft alkylation plays vital role w...
EFFECT OF PIPER NIGRUM (LINN.) ON INFERTILITY INDUCED BY ETHIONAMIDE AND PARA AMINO SALICYLIC ACID IN MALE SPRAGUE-DAWLEY RATS
Tuberculosis is a global problem. The tuberculosis is the common cause of male infertility in developing countries due to the use of second-line anti-tuberculosis drugs (ATB). The experiments were conducted at Unique Bio...
PREVALENCE OF ANEMIA AND ITS ASSOCIATED FACTORS AMONG PREGNANT WOMEN ATTENDING ANTENATAL CENTER IN SHARJAH, UAE
Anemia during pregnancy is a common complication which can involve a mother’s health, baby’s health, or both. Socioeconomic status is affecting the prevalence of maternal anemia, which is varied substantially across regi...
ANTIANXIETY AND ANTIDEPRESSANT ACTIVITY OF VALERIANA PYROLAEFOLIA
Aim of the present study was to evaluate the antianxiety and antidepressant activity of Valeriana pyrolaefolia, a member of family Valerianaceae. The antianxiety and antidepressant activities of dichloromethane extract w...
ANTI-OXIDATIVE, ANTIBACTERIAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF ARTOCARPUS HETEROPHYLLUS SEED EXTRACTS
Artocarpus heterophyllus is an evergreen tree cultivated and consumed throughout Nepal; however, its seed has been neglected as compared to the fruit. The sample was screened for phytochemical evaluation, and general tes...