DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF DASATINIB USING SODIUM STARCH GLYCOLATE AS SUPER DISINTEGRANTS
Journal Title: Innoriginal: International Journal Of Sciences - Year 2017, Vol 4, Issue 1
Abstract
The present study was undertaken to develop immediate release (IR) tablets of Dasatinib a selective tyrokinase inhibitor (TKI) which is used in treatment of chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML).The tablets were prepared by wet granulation method using various excipients, drug and super disintigrants such as sodium starch glycolate (SSG). The prepared tablets were evaluated for pre compression parameters, post compression parameters, in vitro drug release study and stability study. Among the prepared formulations F5 Batch shows 91.32% drug release in 45minutes.The best formulation F5 batch indicates no significant changes from short term stability studies(at 40±2ºC/75±5% RH).Fourier Transform Infrared spectroscopy(FTIR) confirms no drug excipients interaction from various batches
Authors and Affiliations
Chinmaya Keshari Sahoo, MUVVALA SUDHAKAR, SATYABRATA BHANJA, UTTAM PRASAD PANIGRAHY, KANHU CHARAN PANDA
Keywords
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