PHARMACOLOGICAL SCREENING FOR ANTI-OBESE ACTIVITY OF AQUEOUS ROOT EXTRACT FROM IPOMOEA SEPIARIA KOENING EX. ROXB IN HIGH FAT DIET-INDUCED OBESE MALE WISTAR RATS.
Journal Title: Innoriginal: International Journal Of Sciences - Year 2017, Vol 4, Issue 2
Abstract
Effect of Ipomoea sepiaria aqueous root extract on high cholesterol diet rats was investigated. Obesity was induced in rats by giving high cholesterol diet (coconut oil, grains, sugar, etc) for seven days in standard rat chow diet. The aqueous extract of Ipomoea sepiaria (100,200 mg/kg body weight) was orally administered once a day to rats fed a high cholesterol diet for 30 days. High cholesterol-fed diet rats exhibited a significant increase in total serum cholesterol, triglycerides, low-density lipoproteins, very low-density lipoproteins and a significant decrease in high-density lipoproteins. Treatment with aqueous extract of Ipomoea sepiaria significantly decreased total serum cholesterol, triglycerides, low-density lipoproteins, very low-density lipoproteins and increased the high-density lipoproteins in obese rats and was comparable with that of standard Atorvastatin. After completion of experiment rats were anesthetized with Isoflurane and sacrificed and the atheroscelerotic lesions in the aorta were assessed. The obtained results of the investigation of all 5 groups were compared and found with significant inhibition of atheroscelerotic plaque formation.Although a clear dose-dependent relationship was observed at the applied doses. Hence, it was concluded that significant anti-obese and atherosclerotic activities of Ipomoea sepiaria may be due to the presence of carbohydrates, tannins, phenols, flavonoids, proteins, amino acids and saponins found in the preliminary phytochemical screening.
Authors and Affiliations
G. V. PAVAN KUMAR, POOJA. BOYAPATI
Keywords
Related Articles
- EP ID EP431209
- DOI -
- Views 128
- Downloads 0
MEDICINAL PROPERTIES OF BLACK TURMERIC: A REVIEW
Commonly known as ‘Black Turmeric’ is a perennial herb with bluish-black rhizome of the family Zingiberaceae. This species has been gradually increasing in popularity in the interested community for its unmatched medicin...
AN EPIDEMIOLOGICAL SURVEY OF HYPERTENSION
Epidemiological surveys of hypertension on 500 volunteers were conducted, in which 137 volunteers were hypertensive. During the Epidemiological study, it was observed that sedentary life style, āmapradoshaka aahar & viha...
PHYTOCHEMICAL COMPOSITION AND LARVICIDAL ACTIVITY OF ESSENTIAL OIL FROM THE LEAVES OF PLEIOSPERMIUM ALATUM (WALL. EX WT. & ARN) SWINGLE AGAINST AEDES AEGYPTI, ANOPHELES STEPHENSI AND CULEX QUINQUEFASCIATUS (DIPTERA: CULICIDAE)
Objective: The present study was conducted to evaluate the essential oil from the leaves of Pleiospermium alatum (Wall. ex Wt. & Arn) Swingle (Rutaceae) was evaluated for mosquito larvicidal activity against the larvae o...
OVERVIEW ON ANTI-ACNE ACTIVITY OF METHANOL EXTRACT OF DRIED FRUITS OF EMBELIA RIBES
Objective:The present work was undertaken to validate the folk use of traditional Indian medicinal plant in the treatment of skin disorder by using scientific methods. Method:The anti-acne potential of methanol extract o...
AYURVEDIC DRUGS USED IN THE PREPARATION OF KSHARA-SUTRA IN ANO RECTAL DISORDERS W.S.R. PILES,FISTULA
It is quite common for a patient to seek treatment of this disease through surgical intervention because this is only alternative known to the modern medical practitioners and the public in general. In modern surgery the...