MULTIVARIATE CHEMOMETRIC MODELS USED FOR THE ANALYSIS OF RAFOXANIDE IN PRESENCE OF ITS ALKALINE DEGRADATION PRODUCT
Journal Title: Innoriginal: International Journal Of Sciences - Year 2018, Vol 5, Issue 2
Abstract
Objective: Development and validation of three simple, accurate and precise chemometric models for the determination of rafoxanide in the presence of its alkaline degradation product without preliminary separation. Methods: These methods are classical least square (CLS), principal component regression(PCR) and partial least square (PLS-1). A 2-factor 5-level experimental design was built leading to 25 mixtures containing different ratios of rafoxanide and its alkaline degradation product. Thirteen mixtures were used as a training set, and the other twelve were used as a validation set. Results: Using of multi-wavelengths instead of the single wavelength spectrophotometry has greatly improved the precision and predictive abilities of these multivariate calibrations. Conclusion: The proposed methods have been found to be accurate, precise and can be used for determination of the drug in pure form and pharmaceutical formulations as well as in the presence of its degradation product without any preliminary separation steps.
Authors and Affiliations
AHMED H. ABDEL-MONEM, MOHAMMED W. I. NASSAR, KHALID A. M. ATTIA, AHMAD A. MOHAMAD, RAGAB A. M. SAID
Keywords
Related Articles
- EP ID EP550300
- DOI -
- Views 114
- Downloads 0
ELECTROCHEMICAL DETERMINATION OF AMLODIPINE BESILATE AND BENAZEPRIL HYDROCHLORIDE IN THEIR BINARY MIXTURE USING PVC AND COATED GRAPHITE SENSORS
Objective: Design and prepare two ion selective electrodes, Amlodipine–PVC sensor and Benazepril–coated graphite sensor for determination of amlodipine besilate and benazepril hydrochloride in their binary mixture. Metho...
DEVELOPMENT AND OPTIMIZATION OF HYDRODYNAMICALLY BALANCED GASTRORETENTIVE FLOATING TABLETS OF ATENOLOL
The present work was aimed to develop a floating drug delivery system of Atenolol based on novel approaches and to investigate there In vitro drug release and buoyancy performance. The interaction between the excipcents...
NATIVE SPECTROFLUORIMETRIC DETERMINATION OF AMPROLIUM IN BULK AND PHARMACEUTICAL FORMULATION
Objective: The manuscript discussed the application of a simple, accurate and precise spectrofluorimetric method for determination of amprolium in bulk and pharmaceutical formulation. Method: The emission was measured at...
MATHEMATICAL PROCESSING FOR SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF CYCLOPENTOLATE AND PHENYLEPHRINE IN THEIR BINARY MIXTURE
Objective: Development and validation of three simple, accurate, selective and and low cost spectrophotometric methods for simultaneous determination of cyclopentolate hydrochloride (CLO) and phenylephrine hydrochloride...
AYURVEDIC DRUGS USED IN THE PREPARATION OF KSHARA-SUTRA IN ANO RECTAL DISORDERS W.S.R. PILES,FISTULA
It is quite common for a patient to seek treatment of this disease through surgical intervention because this is only alternative known to the modern medical practitioners and the public in general. In modern surgery the...