DEVELOPMENT AND EVALUATION OF ORALLY DISINTEGRATING TABLETS OF METOPROLOL TARTRATE BY DIRECT COMPRESSION METHOD USING DIFFERENT DILUENTS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
The objective of the present investigation was to prepare orally disintegrating tablets of metoprolol tartrate by direct compression method using different concentration of cross povidone as super disintegrants and different diluents. ,Diluents are inactive substance used as carrier for the active ingredients .In the present work, an attempt as been made to prepare tablets with different diluents mannitol, spray dried lactose and di-basic calcium phosphate at different concentration. Orally disintegrating tablet is the fast growing and highly accepted drug delivery system, convenience of self administration, compactness and easy manufacturing. Metoprolol tartrate is an antihypertensive agent, half life is 3 hrs and bioavailability is 40%. It is completely absorb after oral administration. The blend was examined for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The tablets were evaluated for thickness, hardness, friability, and weight variation, content uniformity, wetting time, Water absorption ratio, in-vitro dispersion time, dissolution studies and FTIR studies. Twelve formulations F1 to F12 were prepared with cross povidone as a super disintegrants and three different diluents with different concentration. The optimum formulation was chosen and their optimum results were found to be in close agreement with experimental finding.
Authors and Affiliations
Senthil Adimoolam , Bindu. S Hima , Hardik Kumar Thakkar , Assain Kk Jamsheer , Byrappa Vontoor
Keywords
Related Articles
- EP ID EP108491
- DOI -
- Views 114
- Downloads 0
INVITRO ANTIOXIDANT AND PHYTOCHEMICAL EVAULATION OF DESMODIUM TRIANGULARE (RETZ.) MERR. ROOT
The present study was aimed to investigate the antioxidant potential of the root of Desmodium triangulare (Fabaceae). 70% Methanolic extract was screened by using in vitro by antioxidant activity screening models such a...
PHARMACOGNOSTIC AND PHYTOCHEMICAL EVALUATION OF OUGENIA DALBERGIOIDES BARK
Ougenia dalbergioides (Fabaceae), is commonly known as Sandan. It is reported to have good medicinal values in traditional system of medicine. According to Ayurveda the bark is used in dysentery, leucoderma, urinary dis...
FORMULATION DEVELOPMENT AND EVALUATION OF EFAVIRENZ AND LAMIVUDINE IMMEDIATE RELEASE TABLETS: A COMBINATION THERAPY
The present study outlines a systematic approach for Formulation and Evaluation of Immediate release Tablets of lamivudine and Efavirenz. The objective of this regimen is, to delay disease progression, to increase the du...
EFFECT OF TEMPERATURE ON BINDING PROPERTIES OF NATURAL GUM
Different binding agents can be useful in achieving various tablet mechanical strength and drug release properties for different pharmaceutical purpose. The major application of gums in tablet is as binding agent. The ba...
STUDY OF ANTIOXIDANT ACTIVITY WITH REDUCTION OF DPPH RADICAL AND XANTHINE OXIDASE INHIBITOR OF THE EXTRACT OF RUELLIA TUBEROSA LINN LEAF
Ruellia tuberosa L belongs to Acanthaceae family. In traditional medicine has been used as diuretic, antidiabetic, antipyretic and antihypertensive, and it also recently been incorporated as a component in a herbal tea i...