Development and Evaluation of Pelletized Delivery System for Effective Treatment of Type Ii Diabetes by Using Extrusion and Spheronization Technique
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 4
Abstract
Diabetes mellitus is a group of metabolic disorders of carbohydrate metabolism in which glucose is underutilized, producing hyperglycemia resulting from a defect in insulin secretion, insulin action, or both. Type 2 diabetes comprises 90% of people with diabetes around the world, and is largely the result of excess body weight and physical inactivity. In these patients, sulphonyl ureas (glimepiride) and biguanide (metformin) are the most commonly prescribed oral treatment options. Because of their complementary mechanism of action, combination therapy with a sulphonyl urea and biguanide rational is this combination lead to benefits in terms of improved glycaemic control and improved tolerability at lower doses of the individual agents. In this study, Metformin hydrochloride sustained release multiparticulate drug delivery system in combination with Glimepiride and Pioglitazone Immediate release multiparticulate drug delivery system were formulated. It was found that Metformin pellets which provide superior release profile than marketed formulations over a period of 12 hours. In case of Glimepiride pellets provides more than 85% drug release which shows superior drug release profile than marketed formulations. Key Words Metformin Hydrochloride, Glimeperide, Diabetes mellitus, sustained release, pellets.
Authors and Affiliations
Vandana Y Dhanorkar, Dr. P. Shah
Keywords
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- EP ID EP395536
- DOI 10.9790/3008-1304033445
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