DEVELOPMENT AND IN-VITRO EVALUATION OF METOPROLOL SUCCINATE CONTROLLED POROSITY OSMOTIC PUMP TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 4
Abstract
In the present research work, attempts were made to develop and evaluate Sustained release formulation of Metoprolol succinate based on osmotic technology.As Metoprolol is a short acting drug, developed formulation provides the advantages of controlled release formulations. The developed formulation provides advantages of less steps of manufacturing procedure, no need of laser drilling, and economical. All of these made the procedure easily amenable to mass production using conventional tablet machines. Metoprolol 50mg core formulation was prepared using osmogents and coated with different coating formulae to optimize film former (cellulose acetate): pore former (sorbitol) ratio. The effect of different formulation variables namely, membrane weight gain, and amount of pore former in the membrane, were studied. Metoprolol release was inversely proportional to the membrane weight (coating thickness) but directly related to the initial amount of pore former (sorbitol) in the membrane. All polymers and excipients used in optimized formula were found to be compatible with the drug and it was confirmed by FT-IR studies. Drug release from the developed formulations was independent of pH and agitational intensity. The drug release from formulation was proved as dependent on osmotic pressure only. The number of pores was directly proportional to the amount of pore former in the membrane. The manufactured formulations were stable after 45 days of accelerated stability studies.
Authors and Affiliations
Anil Veeramalla , Vamshikrishna Madishetty , Rajendra Indarapu , Raj Gudikandula , Srinivas Kadari
Keywords
Related Articles
- EP ID EP161753
- DOI 10.7897/2230-8407.04435
- Views 120
- Downloads 0
DEVELOPMENT AND IN VITRO CHARACTERIZATION OF NANOEMULSION AS ADJUVANT FOR THE ADMINISTRATION OF VACCINE USING A MODEL ANTIGEN
The present study has investigated the development of oil in water type nanoemulsion (NE) for the incorporation of vaccine. NE act as adjuvant and potentiate the immunogenicity of antigen. The NE was formulated using pla...
VALIDATED ESTIMATION OF CAPECITABINE BY UV-SPECTROSCOPIC, RP-HPLC AND HPTLC METHOD
This paper describes the Quantitative estimation of Capecitabine in pure powder and its pharmaceutical dosage form by UV spectroscopy (geometric correction method), RP – HPLC and HPTLC methods. In the UV method, ge...
MACROSCOPIC AND MICROSCOPIC CHARACTERIZATION OF THE AERIAL PARTS OF TRIBULUS ALATUS (ZYGOPHYLLACEAE) GROWING IN EGYPT
Tribulus alatus is a promising medicinal plant. Macroscopic and microscopic studies were carried out on leaflet, rachis, stem and fruit as well as powdered aerial parts. Powder microscopy revealed the presence of anomocy...
MOUTH DISSOLVING FILM AND THEIR PATENT: AN OVERVIEW
Now days the researchers are focusing on the fast dissolving dosage form (FDDF’s).The fast dissolving dosage forms includes the mouth dissolving tablets, mouth dissolving thin films .The alternative words used for thes...
AN UPDATED OVERVIEW ON PEPPERMINT (MENTHA PIPERITA L.)
Mentha piperita L. (Family: Lamiaceae; Synonym: M. balsamea Wild; commonly known as peppermint) is a natural hybrid (M. aquatica × M. spicata) with immense therapeutic uses (oldest known medicinal plant species, “medicin...