Development and optimization of Diltiazem hydrochloride loaded microspheres by using different Eudragit polymers
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 6
Abstract
The problems of frequent administration and variable low bioavailability (40-60%) after oral administration of conventional dosage forms of Diltiazem hydrochloride can be attenuated by designing it in the form of microspheres which would prolong the residence time at the absorption site to facilitate intimate contact with the absorption surface and thereby improve and enhance the bioavailability. Microspheres of Diltiazem hydrochloride were formulated using Eudragit S 100 and Eudragit L 100 alone by solvent evaporation methods with an aim to prolong its release. Six formulations prepared by using different drug to polymer ratios, were evaluated for relevant parameters. Depending upon the drug to polymer ratio, the entrapment efficiency were found to range between 86.11 ± 0.37, 88.84 ± 0.28, 91.80 ± 0.29, 94.38 ± 0.26, 95.57 ± 0.39, 98.11 ± 0.29 respectively. The scanning electron microscopic study indicated that the microspheres were spherical in shape and the drug remained dispersed in the polymer matrix at amorphous state, In vitro studies were carried out at different pH for a period of 12 hours. Drug polymer interaction was absent as evidenced by FT-IR.
Authors and Affiliations
V. Kamalakkannan ,K. S. G. Arul Kumaran
Keywords
Related Articles
- EP ID EP33146
- DOI -
- Views 315
- Downloads 0
Benign prostate hypertrophy and its treatment
Benign prostate hypertrophy (BPH), as the name suggests, it’s a noncancerous enlargement of the prostate gland. The enlargement compresses the urethra which passes through the center of the prostate gland. It obstructs...
RP-HPLC DEVELOPMENT AND VALIDATION OF ASSAY AND UNIFORMITY OF DOSAGE UNITS BY CONTENT UNIFORMITY FOR IN HOUSE LAMIVUDINE AND ABACAVIR COMBINED TABLET
A precise, accurate, highly sensitive, rugged and robust HPLC method has been developed and validated for the assay and content uniformity of Lamivudine and Abacavir in combined tablets. The method was developed using...
Soil analysis of Pothavaram village, Prakasam district, Andhra Pradesh, India for the determination of Organic Matter, Sulphur, Zinc and Boron
Soil analysis was conducted in Pothavaram village, Prakasam District, Andhra Pradesh, India, for the determination of Organic matter, Sulphur, Zinc and Boron. Soil analysis is a useful tool for the estimation of micro...
RECENT TRENDS IN POLYMER USE IN BIOADHESIVE DRUG DELIVERY SYSTEM
Bioadhesion can be defined as the process by which a natural or a synthetic polymer can adhere to a biological substrate. When the biological substrate is a mucosal layer then the phenomena is known as mucoadhesion. Th...
Analytical method development for the simultaneous estimation of Hydrochlorothiazide and Atenolol in combined tablet formulation by RP-HPLC
A Simple, accurate, rapid, sensitive and precise Rp-Hplc method has been developed for estimation of Hydrochlorothiazide and Atenolol in tablet dosage form using PDA detector. A Reverse phase Thermo Hypersil ODS c18 co...