DEVELOPMENT AND OPTIMIZATION OF ORODISPERSIBLE TABLETS OF CARVEDILOL BY COMBINATION OF SUPER-DISINTEGRANTS ADDITION AND SUBLIMATION TECHNIQUES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 7
Abstract
Objective: Objective of the present research work was to prepare orodispersible tablets of carvedilol (CDL) for dysphagic patients.Methods: Carvedilol, an anti-hypertensive drug, was chosen as a model drug in this study. Orodispersible tablets of carvedilol were prepared using different super-disintegrating agents such as crospovidone, croscarmellose sodium and sodium starch glycolate at different concentrations. The best formulation was selected based on disintegration and dissolution profile that was further taken for sublimation studies using camphor, menthol and thymol. Drug-excipients interaction studies were carried out by fourier transform infra-red (FTIR) spectrophotometer with pure drug sample and optimized formulation.Results: The orodispersible tablet formulation having 4% croscarmellose sodium disintegrated in 92 sec. Hence this formulation was considered best formulation and taken further for sublimation studies. A formulation containing 10% w/w of menthol showed disintegration time of 16 sec with more than 96.64% drug release within 15 min. Menthol leaves the porous structure as it sublimates from the tablet. This might have contributed to the decrease in disintegration time. Hence, this formulation was considered optimized.Conclusion: From this study, it can be concluded that orodispersible tablets of carvedilol may prove to be more efficacious in the treatment of hypertension particularly in dysphagic patients.
Authors and Affiliations
Vijayanand P. , Sridevi P. , Bhagavan Raju M.
AWARENESS ON CERVICAL CANCER-RISK ASSESSMENT
Objective: To create awareness on cervical cancer, a level of knowledge about cervical cancer, to be advised of effective screening procedures based on their risk assessment, to educate about preventive measures after sc...
EFFECT OF MENTHA PIPERATA IN EXPERIMENTAL PROSTATIC HYPERPLASIA IN WISTAR ALBINO RATS
Objective: To investigate the protective efficacy of Mentha piperata in experimental benign prostatic hyperplasia in Wistar albino rats.Methods: Benign hyperplasia of prostate was induced by subcutaneous injection of t...
PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF ESBL PRODUCING GRAM NEGATIVE BACILLI IN 200 CASES OF URINARY TRACT INFECTIONS
Objective: Isolation and identification of Extended Spectrum Beta Lactamases from urinary isolates and to study their drug sensitivity pattern.Methods: The study was done on 200 patients with suspected urinary tract infe...
MICROBICIDAL POTENTIALITY OF PURIFIED ANTHOCYANIN FROM IN VITRO CULTURE OF CLERODENDRON INFORTUNATUM L. AGAINST SELECTED PATHOGENS
Objective: Clerodendron infortunatum L. is a widely used medicinal herb over centuries for curing many skin-borne disorders. The present study was designed to validate the tribal knowledge by evaluating antimicrobial pot...
NEAR-INFRARED SPECTROSCOPY: A POTENTIAL NEW MEAN OF ASSESSING MULTICOMPONENT POLYHERBAL FORMULATION ON WAY BEFORE AND AFTER EXTRACTION
Objective:Traditional polyherbal medicine and their preparations have been widely used for the thousands of years in developing and developed countries owing to its natural origin and lesser side effects or dissatisfacti...