Development and Validation of UV-Spectrophoto-metric Method for Determination of Palladium Content in Rasagiline Mesylate
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 15, Issue 4
Abstract
A simple, precise, linear, accurate and robust spectrophotometric method was developed for the estimation of palladium content in Rasagiline Mesylate. The proposed method is based on complex formation of palladium with α-nitroso-β-napthol in alkaline medium and extraction with toluene and estimation. The spectrum shows maximum absorption at 425 nm. The method is validated as per on International council for harmonization (ICH) guidelines. The absorbance-concentration plot is linear over the concentration range of 3.08 to15.38 ppm with limit of detection (LOD) of 0.06 ppm and limit of quantification (LOQ) of 0.17 ppm. The recovery of Palladium in Rasagiline Mesylate obtained was between 95 to 105 %. The proposed method can be applied for the determination of palladium content in Rasagiline Mesylate.
Authors and Affiliations
Sayyed Hussain, Amit Gosar, Tabrez Shaikh
Keywords
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- EP ID EP313052
- DOI 10.9734/BJPR/2017/32254
- Views 118
- Downloads 0
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