Diagnostic Value of Pre treatment Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Lymphocyte-to-Monocyte Ratio for Invasive Bladder Carcinoma
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 5
Abstract
Purpose: Oncologic outcomes in diverse malignancies are associated with inflammation-based prognostic scores including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyteto-monocyte ratio (LMR). In this study, we evaluated the predictive value of pre treatment prognostic scores in differentiating muscle invasive (MIBC) and non muscle invasive (NMIBC) bladder cancer. Materials and Methods: This prospective cross sectional study analysed consecutive transurethral resection of bladder tumour (TURBT) cases from September 2016 to December 2017. Demographics of patients, characteristics of tumour and prognostic scores results were recorded. Prognostic score cut offs were determined using receiver operating characteristics curves. The association between variables and MIBC were evaluated by performing univariate and multivariate binomial logistic regression analysis. Results: Total patients included were 142. Of this 96 were having NMIBC (stage T1) and 46 were having MIBC (stage T2+). Median age was 75 years. 128 patients were male(90.1%) and 14 were female(9.9%). The NLR had the greatest area under the curve (AUC) of 0.748 (cut off was 3.89), followed by LMR (cutoff<1.8; AUC, 0.644) and PLR (cut off>218; AUC, 0.596). Univariate analysis identified NLR, PLR, LMR, Tumour size and Tumour multiplicity as significant predictors of muscle-invasive bladder cancer (MIBC) Table: 15. The multivariate logistic regression model identified NLR (OR, 11.822; 95% CI, 4.492 – 31.112; p=0.001) and tumour size (OR, 6.306; 95% CI, 1.563 – 25.436; p=0.010) as independent predictors of muscle-invasive bladder cancer (MIBC). Conclusions: NLR may be used as a simple, cost-effective and easily measured marker for MIBC. It can be performed at the time of diagnostic cystoscopy, and can be used in the planning of further treatment.
Authors and Affiliations
N. Madhavan
Keywords
Related Articles
- EP ID EP515784
- DOI -
- Views 70
- Downloads 0
Study on Pattern of Thoraco-Abdominal Injuries in Fatal Road Traffic Accidents at Ranchi, Jharkhand
Road traffic injuries are one of the major causes of morbidity and mortality in developing countries including India and are a major health and social problem. Trauma affects generally the young people, and accounts for...
To Study the Clinical Profile of Tuberculosis in HIV Positive Patients and Impact of Antitubercular Therapy
Background: There is paucity of data from peripheral centres on clinical profile of Tuberculosis in HIV positive patients and outcome of those patients to chemotherapy. Methods: An observational study of HIV TB co infect...
Role of Prophylactic Antibiotics in Bladder Management of Paraplegics – A Randomised Controlled Study
Introduction: Traumatic spinal cord injury is not an uncommon disease in the developing world. The most common cause being fall from heights. In spinal cord injured patients both bladder sensation and control are impaire...
Effect of Mechanical Closure of Dead Space on Seroma Formation in Modified Radical Mastectomy
Breast carcinoma is a common malignancy among women and the most common of complications associated with modified radical mastectomy is the formation of seroma. Various methods have been tried to reduce the incidence of...
Comparison Between Inhibitive Distraction and Intermittent Cervical Traction on Pain and Disability in Patient’s With Non-Specific Neck Pain
Aim: Aim of this study is to assess and compare the effect of cervical traction or inhibitive distraction on pain and disability in Patient with non-specific neck pain. Methodology: 27 Patients were randomly selected fro...