DIFFERENT MODELS OF HEPATOTOXICITY AND RELATED LIVER DISEASES: A REVIEW
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 7
Abstract
The liver is among the most complex and important organs in the human body. Its primary function is to control the flow and safety of substances absorbed from the digestive system before distribution of these substances to the systemic circulatory system. Hepatotoxicity implies chemical-driven liver damage. Chemicals that cause liver injury are called hepatotoxins. Hepatic injury leads to disturbances in transport function of hepatocytes resulting in leakage of plasma membrane thereby causing an increased enzyme level in serum. There are many diseases that are related with hepatotoxicity caused by certain chemicals or hepatotoxins. Herbal medicines are great demand in various chemicals and drugs disordered hepatic, the developed world for primary health care because of their efficacy, safety, lesser side effects and narrow therapeutic window. This review focus on liver, its function, liver diseases and different models of hepatotoxicity.
Authors and Affiliations
Robin Singh , Sunil Kumar , A. C. Rana , Nidhi Sharma
Keywords
Related Articles
- EP ID EP150924
- DOI -
- Views 97
- Downloads 0
ANTIDEPRESSANT ACTIVITY OF HYDROALCOHOLIC EXTRACT OF ZINGIBER OFFICINALE
The present study was design to evaluate the effect of Zingiber officinale hydro-alcoholic extract as well as its interaction with conventional anxiolytic and antidepressant drugs using tail suspension test and forced sw...
EXPERIMENTAL STUDIES ON ACTIVE METABOLITES OF CALOTROPIS GIGANTEA FOR EVALUATION OF POSSIBLE ANTIFUNGAL PROPERTIES
The active metabolites like phytochemicals from the medicinal plants were under exploration for the development of novel and biodegradable effective drugs as an alternative to the ineffective contemporary medicine. In th...
SYNTHESIS, CHARACTERIZATION OF SOME NOVEL PYRAZOLES AND THEIR GROWTH PROMOTING ACTIVITY ON SOME FLOWERING PLANTS
A series of chlorosubstituted 4-aroylpyrazoles have been synthesized by refluxing of chlorosubstituted-3-aroylflavones and 3-alkoylchromone with phenylhydrazine hydrochloride in dioxane medium with 0.5 ml of piperidine....
A STUDY ON ETHNOMEDICINAL USES OF PLANTS IN DHEMAJI DISTRICT OF ASSAM WITH SPECIAL REFERENCE TO REPRODUCTIVE HEALTH
The present paper deals with the documentation of ethnomedicinal uses of plants and parts, particularly the fertility and anti-fertility plants used by the Misings, Kacharis & Chutias of Dhemaji district of Assam, In...
ASSESSING THE PATTERN OF DRUG USE AMONG PREGNANT WOMEN AND EVALUATING THE IMPACT OF COUNSELLING ON MEDICATION ADHERENCE AMONG THEM
In the present study an attempt is made to assess the pattern of drug use among pregnant women and to evaluate the impact of counseling on medication adherence by providing patient education regarding pregnancy. During t...