Drug resistance profile of Klebsiella Species from clinical isolates in a tertiary care hospital
Journal Title: Medpulse International Journal of Microbiology - Year 2018, Vol 7, Issue 2
Abstract
Background: Klebsiella species are widely distributed in nature occurring as commensals in intestines and saprophytes in soil and water. These are associated with wide variety of opportunistic and nosocomial infections, such as pneumonia, U.T.I, wound infections and septicemia. Increasingly, they have developed antimicrobial resistance, notably to various Cephalosporins and Carbapenems resistance is also on the rise which is of growing concern worldwide. Objectives: Antibiotic susceptibility pattern of Klebsiella species along with E.S.B.L production from various clinical isolates. Material and Methods: A total of 244 isolates of Klebsiella species were obtained from various clinical samples identified by standard laboratory procedures. Isolates were subjected to susceptibility testing against various antibiotics by disc diffusion test as per C.L.S.I guidelines. Isolates resistant to 3rd Generation Cephalosporins were tested for E.S.B.L production by using phenotypic confirmatory tests. Results: Of the 244 isolates, highest isolation rate was from sputum (40.5%), followed by urine (38.5%), exudate (15.5%), blood (3.27%) and pleural fluid (2.04%). The resistance rate of Klebsiella species for 3rd Generation Cephalosporins was around (45%), Gentamicin (30.3%), Cotrimoxazole (33%), Ciprofloxacin (32%), Lomefloxacin (30%) and Levofloxacin (34%). Maximum sensitivity was seen against Piperacillin-Tazobactam (65%) and Imipenem (89.2%). 37% of isolates were confirmed by phenotypic confirmatory tests as E.S.B.L producers. Conclusion: Regular monitoring and judicious use of antibiotics helps in preserving the effectiveness of sensitive antibiotics and controls the emergence of further resistance.
Authors and Affiliations
Mohammed Amer, Humera Qudsia Fatima Ansari
Keywords
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