Drug resistance profile of Klebsiella Species from clinical isolates in a tertiary care hospital
Journal Title: Medpulse International Journal of Microbiology - Year 2018, Vol 7, Issue 2
Abstract
Background: Klebsiella species are widely distributed in nature occurring as commensals in intestines and saprophytes in soil and water. These are associated with wide variety of opportunistic and nosocomial infections, such as pneumonia, U.T.I, wound infections and septicemia. Increasingly, they have developed antimicrobial resistance, notably to various Cephalosporins and Carbapenems resistance is also on the rise which is of growing concern worldwide. Objectives: Antibiotic susceptibility pattern of Klebsiella species along with E.S.B.L production from various clinical isolates. Material and Methods: A total of 244 isolates of Klebsiella species were obtained from various clinical samples identified by standard laboratory procedures. Isolates were subjected to susceptibility testing against various antibiotics by disc diffusion test as per C.L.S.I guidelines. Isolates resistant to 3rd Generation Cephalosporins were tested for E.S.B.L production by using phenotypic confirmatory tests. Results: Of the 244 isolates, highest isolation rate was from sputum (40.5%), followed by urine (38.5%), exudate (15.5%), blood (3.27%) and pleural fluid (2.04%). The resistance rate of Klebsiella species for 3rd Generation Cephalosporins was around (45%), Gentamicin (30.3%), Cotrimoxazole (33%), Ciprofloxacin (32%), Lomefloxacin (30%) and Levofloxacin (34%). Maximum sensitivity was seen against Piperacillin-Tazobactam (65%) and Imipenem (89.2%). 37% of isolates were confirmed by phenotypic confirmatory tests as E.S.B.L producers. Conclusion: Regular monitoring and judicious use of antibiotics helps in preserving the effectiveness of sensitive antibiotics and controls the emergence of further resistance.
Authors and Affiliations
Mohammed Amer, Humera Qudsia Fatima Ansari
Keywords
Related Articles
- EP ID EP414092
- DOI -
- Views 95
- Downloads 0
Prevalence of dermatophytes and other fungal agents from clinical specimens at a tertiary care hospital
Background: Superficial fungal infections are the most common skin diseases, affecting millions of people throughout the world. The present study was undertaken to isolate dermatophytes and other fungal agents from clini...
Utility of GeneXpert as a diagnostic tool for extra pulmonary tuberculosis
Background: India has the highest tuberculosis (TB) burden with high rates of MDR TB. Conventional TB culture considered as the gold standard often leads to considerable delay in diagnosis. GeneXpert newer diagnostic mod...
Burden of hepatitis B virus infection at tertiary care hospital
Background: Hepatitis B is a life threatening disease, endemic throughout the world especially in tropical and developing countries like India. Prevalence of this infection varies in different geographical areas. Estimat...
Prevalence of subcutaneous mycosis in a tertiary care centre
Background: The incidence of subcutaneous mycosis and associated fungal species varies in different geographic region. It seems to be increasing in some tropical region.Objective:1. To determine the prevalence of infecti...
Seroprevalence and seasonal trend of dengue virus infection at tertiary care hospital, Valsad
Background: Dengue is a vector borne febrile illness affecting tropical and subtropical regions of world including India. It is major public health problem in India because of rapid explosive urbanisation and absence of...