Early diagnosis of diabetic nephropathy using spot urine microalbumin in type 2 diabetes mellitus patients
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 9, Issue 1
Abstract
Background: The studies using newer diagnostic methods to detect urinary albumin excretion (UAE) sub-clinically have given hopes of detecting early nephropathy and possible intervention to retard or reverse nephropathy at that stage. The present study is carried out to assess HbA1c, lipid profile and urine microalbumin in type 2 diabetic patients. Material and methods: The present study was carried out on 30 type 2 diabetic patients, and 30 normal healthy controls included both males and females in the age group of 30 years to 70 years from government General hospital, Kurnool. Results: The urinary microalbumin, total cholesterol, triglycerides, HDL, VLDL, and LDL in diabetic cases are in the range of 94.10 ±12.80 mg/l, 193.4 ±10.73 mg/dL, 196.6±18.26 mg/dL, 34.4±3.6 mg/dL, 39.3±2.5 mg/dL, 119.6 11.5 mg/dL respectively and in controls are in the range of 18.86±1.50 mg/l, 164±6.5 mg/dL, 135.86±10.80 mg/dL, 46.6±4.2 mg/dL, 27.16±2.29 mg/dL, 91.1±7.26 mg/dL respectively were increased in diabetic cases when compared to controls, whereas HDL is decreased in diabetic cases when compared to controls. The increase is highly significant for urinary microalbumin, Lipid profile values (P<0.001 and P<0.001) and decrease is significant for HDL (P < 0.001), and there was a positive correlation between triglyceride and urine microalbumin. Conclusion: Microalbuminuria in type 2 diabetic patients is associated with hyperlipidemia may represent a risk factor for cardiovascular disease and may contribute to the progression of renal disease and early detection and treatment prevent development of end stage renal disease.
Authors and Affiliations
Veera Sudhakar Ketham, B Ravindra Reddy, A Padma Vijaya Sree
Keywords
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- EP ID EP485894
- DOI 10.26611/1002911
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