EFFECT OF ETHANOLIC LEAF EXTRACTS OF CARICA PAPAYA AND NEWBOULDIA LAEVIS ON KIDNEY ENZYMES OF ALLOXAN-INDUCED DIABETIC WISTAR RATS.
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 5
Abstract
Objective: This study was carried out to investigate the effect of the ethanolic leaf extracts of C. papaya and N. laevis on kidney enzymes of alloxan-induced Wistar rats. Methodology: Forty male Wistar rats weighing between 160g ā 200g were randomly assigned to eight Groups A - H of 5 rats each. Group A served as the control group and was not induced with diabetes, while Groups B ā H were induced. Groups A and B received distilled water only, while Groups C - H received 200mg/kg of C. papaya, 400mg/kg of C. papaya, 200mg/kg of N. laevis, 400mg/kg of N. laevis, 200mg/kg of C. papaya + 200mg/kg of N. laevis and 400mg/kg of C. papaya + 400mg/kg of N. laevis respectively for 28 days. On day 29 of the experiment, the final weights of the animals were determined and they were sacrificed; blood samples were collected from each of the animals for serum analysis. Results: There were significant (PĖ0.05) increase in serum levels of urea and creatinine of the animals in group B when compared with the control group. These effects were ameliorated in Groups C - H which received the variable doses of the ethanolic leaf extracts with more positive effects on the Groups that received the combined ethanolic leaf extracts. Conclusion: This study has revealed that ethanolic leaf extracts of C. papaya and N. laevis have ameliorative effects on the body weight and serum levels of urea and creatinine on alloxan-induced Wistar rats.
Authors and Affiliations
Mr. Ifegwu N. O.
Keywords
Related Articles
- EP ID EP673308
- DOI -
- Views 161
- Downloads 0
GASTRIC STROMAL TUMORS: ABOUT THREE CASES
Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the digestive tract. These tumors were the object of numerous controversies in terms of histogenesis and of classification. They become...
INCIDENCE OF DOWN'S SYNDROME AND ASSOCIATED RISK FACTORS AT MCH, BURAYDAH, QASSIM REIGON K.S.A.
Introduction: Down syndrome (DS), a congenital condition caused by trisomy of human chromosome 21 is the most frequent chromosomal abnormality in live births associated with mental retardation and congenital heart defect...
DOES PUMPKIN AFFECT GLYCEMIC CONTROL IN DIABETIC PATIENT. CASE REPORT AND LITERATURE REVIEW
Pumpkin was reported to have hypoglycemic effect. It has been used in asia as traditional treatment for diabetes mellitus. Here we report 12 year old Saudi who is diagnosed as diabetes mellitus type 1. The pumpkin was fe...
EFFECT OF THE MONGOLIAN MEDICINE "GARLICLAXATIVE" IMPACT THERAPY ON ALCOHOLIC PERIPHERAL NERVE
Objective: Using the Mongolian medicine "Garlic laxative," impact therapy on alcoholic peripheral neuropathy treatment mechanism for the Mongolian medicine application in the study of neurological diseases lay the founda...
RELATIONSHIP BETWEEN OBESITY AND ANTI MULLERIAN HORMONE IN WOMEN ABOVE (35) YEARS OLD
Objective: To study the relationship between obesity and anti mullerian hormone as a serum marker of ovarian reserve in women above age 35 years. Methods: This study was conducted in the infertility center in Basrah Mate...