EFFECT OF HPMC 4 CPS AND CARBOPOL 974P NF ON RELEASE KINETICS OF<br /> CIPROFLOXACIN FROM KOLLIDON® SR EMBEDDED MATRIX TABLETS
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 4
Abstract
Controlled release (CR) Ciprofloxacin (CFX) matrix tablets were prepared using Ciprofloxacin betaine as a model drug and Kollidon® SR as a core matrix former. Kollidon® SR embedded CFX matrix tablets were then characterized with Carbopol 974P NF, Cetyl alcohol, Hydroxypropyl methyl cellulose (HPMC 4.5 cps). CFX release was 74% after 10 hours dissolution in 0.01 N HCl solution from the tablets containing only Kollidon® SR. Though addition of only HPMC 4.5 cps increased the release rate of CFX, combination of HPMC 4.5 cps, cetyl alcohol and Carbopol 974P NF, Cetyl alcohol decreased the release rate of CFX. The increased released rate of CFX from the former formulations might be due to the hydrophilic nature of HPMC 4.5 cps and the reduced CFX release from the latter formulations might be due to the hydrophobic and release retarding nature of Carbopol 974P NF and Cetyl alcohol. Highest MDT value and lowest release rate was 13.54 hour and 14.21 %hr-0.5 respectively for 9% Carbopol 974P NF-18% cetyl alcohol containing tablet. Whereas lowest MDT value and highest release rate was 4.7 hour and 28.48 %hr-0.5 respectively for 27% HPMC 4.5 cps-0% cetyl alcohol containing tablet. CR tablets of CFX followed non-Fickian or anomalous type release. But, polymer relaxation dominated more on CFX release than diffusion from HPMC containing tablets (n were nearer to 0.7) whereas diffusion dominated more on CFX release than polymer relaxation from Carbopol containing tablets (n were nearer to 0.6).
Authors and Affiliations
Md. Asaduzzaman , Md. Saiful Islam , Reza-ul Jalil , Md. Elias-Al-Mamun
Keywords
Related Articles
- EP ID EP123930
- DOI -
- Views 107
- Downloads 0
Evaluation of Anti-ulcer activity of methanolic extract of Terminalia chebula fruits in experimental rats
The anti-ulcer activity of methanolic extract of Terminalia chebula (Combretaceae)fruits METC was investigated in pylorus ligation and ethanol induced ulcer models in wistar rats. In both models the common par...
Study of antioxdant, antiinflammatory and woundhealing activity of extracts of Litsea glutinosa
Present work was undergone to investigate antioxidant and anti inflammatory and wound healing effects of Litsea glutinosa in rats. The aqueous extract of Litsea glutinosa (250 and 500 mg/kg body weight) was studied for a...
Phytochemical and Pharmacological Screening of the Plant Crateva Magna Against Alloxan Induced Diabetes in Rats.
The plant Crateva magna belonging to family Capparaceae is used in anti spasmodic, hypotensive, anti inflammatory, hypoglycemic, anti protozoal, analgesic purposes. The present study was carried out to evaluate the eff...
Pharmacognostical standardization of leaves of Ixora coccinea, linn.
[i]Ixora coccinea LInn.[/i] is traditionally found to be useful for many ailments like hepatoprotective, chemoprotective, antimicrobial, antioxidant, antinociceptive and anti-inflammatory activities. The present study hi...
Inhibition of N-Acyl Homoserine Lactone Mediated Quorum Sensing in Pseudomonas aeruginosa by Phyllanthus emblica and Quercus infectoria
Quorum sensing (QS) is a process that enables bacteria to communicate using secretd signaling molecules called autoinducer. Pseudomonas aeruginosa an opportunistic pathogen in immune compromised patients is under the re...