Effect of Passive Transfer of Spleen Cells from Immunized Mice with Hydatid Cyst Antigens on the Growth of Melanoma Cancer in C57/Black Mice
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 16, Issue 7
Abstract
Background: Anticancer effect of hydatid has been shown in previous investigations. However the mechanism of anticancer effects of hydatid cyst has not been clarified. So in this work the effect of spleen cell transfer immunized by the hydatid cyst antigens on melanoma cancer growth in animal model has been investigated. Methods: Spleen cells of mice immunized with hydatid cyst fluid, cyst wall and protoscoleces were transferred to different group of mice and subsequently challenged with melanoma cells. Then the tumor size, tumor growth rate and survival time of mice were compared with those of control groups. Results: Tumor size, tumor growth rate and mice survival time were significantly lower than what observed in control mice. Conclusion: Immune response to hydatid cyst antigens may be involved in Anti-cancer effect of this parasite.
Authors and Affiliations
Seyedeh Tala Ramazninia, Seyedeh Maryam Sharafi, Mehran Bahadoran, Fereshteh Jafaee Nodeh, Mehdi Mahmoudzadeh, Hossein Yousofi Darani
Keywords
Related Articles
- EP ID EP341282
- DOI 10.9734/BJMMR/2016/26744
- Views 69
- Downloads 0
Hepcidin and Erythropoietin Level in Sickle Cell Disease
Background: Sickle cell anaemia is an inherited disorder in which the red blood cells become rigid and sticky, and change from being disc-shaped to being crescent-shaped. The change in shape is as a result of an abnormal...
Effectiveness of Educational Intervention on Jordanian Nurses’ Knowledge and Attitude Regarding Pain Management
Aim: Although guidelines and pharmacological interventions exist to manage pain, poor assessment and under-medication are prevalent. It was reported that inadequacy of pain management can be due to nurses’ lack of knowle...
Neuropathic Pain in Patients with Sciatica: Prevalence and Related Factors
Aim: To assess the prevalence of neuropathic pain (NP) in patients with sciatica and to determine the associated factors with increased incidence of neuropathic component in sciatica. Methods: A cross-sectional study enr...
Interplay of Chemo Attractant Peptides (Cathelicidin and Chemerin) with Vitamin- D in Patients with Pulmonary Tuberculosis
Aim: Both Cathelicidin and Chemerin are chemo-attractant proteins and possess antimicrobial activity. Sufficient level of Vitamin D is important for optimum response of Cathelicidin for its anti-mycobacterial activity. S...
Bacterial Contamination of Ready to Eat Fruits Sold in and Around Ugbowo Campus of University of Benin (Uniben), Edo State, Nigeria
Fresh fruits are major sources of nutrients and vitamins which help to promote good health. However, fresh fruits may also harbour a wide range of microbial contaminants of public health significance. To assess the bacte...