EFFECT OF POLYMER AND GAS FORMING AGENT ON FLOATING DRUG DELIVERY OF TRAMADOL HYDROCHLORIDE USING RESPONSE SURFACE METHODOLOGY: IN VITRO AND IN VIVO EVALUATION
Journal Title: International Journal of Pharmaceutical Applications - Year 2011, Vol 2, Issue 3
Abstract
Tramadol hydrochloride is a synthetic opioid used as a centrally acting analgesic and effective in both experimental and clinical pain. The half-life of the drug is about 5.5 hours and oral dose is 50 to 100 mg every 4 to 6 hours. To reduce the frequency of administration and to improve patient compliance, a sustained-release formulation of tramadol is desirable. The 32 full factorial design was employed for formulation of tramadol hydrochloride tablets. Sodium bicarbonate was incorporated as a gas-generating agent. The concentration of sodium bicarbonate required for optimum floating ability was finalised by 32 full factorial design along with HPMC K4M independent variable. Combination of polymers hydroxy propyl methyl cellulose (HPMC) grade K4M and hydroxy propyl cellulose (HPC) was used to achieve sustained release effect. The concentration of polymers was considered as the independent variables and dependent variables were floating time, drug content of formulation, and % drug release after 10 hours, swelling index and hardness of the tablets. The drug-excipient compatibility was studied with the help of Infrared-red spectroscopy. In vivo drug release pattern was studied using the X-ray radiographic technique. From the factorial batches, it was observed that formulation containing combination of 10% sodium bicarbonate and 10% citric acid shows optimum floating ability whereas the formulation containing 75 % HPMC K4M and 50% HPC shows optimum sustained drug release pattern with adequate floating. X ray study of the optimised formulations showed gastroretention for 6 hrs indicating successful floating GRDDS of tramadol HCl.
Authors and Affiliations
Swati C. Jagdale , Swapnil A. Ghorpade , Bhanudas S. Kuchekar , Aniruddha R. Chabukswar
PHARMACOLOGICAL EVALUATION OF CATHARANTHUS ROSEUS
The present work is aimed at evaluating antibacterial and antidiabetic activities of whole plant extract of Catharanthus roseus. Dichloromethane: methanol (1:1) extract was used for carrying out in-vitro antibacterial a...
THE BENEFICIAL EFFECT OF ETHANOLIC EXTRACT OF MORINGA OLEIFERA ON OSTEOPOROSIS
Several animal and clinical studies have shown that phytoestrogens, plant derived estrogenic compounds can be useful in treating post menopausal osteoporosis. Phytoestrogens and phytoestrogen containing plants are...
HEPATOPROTECTIVE ACTIVITY OF BOSWELLIA SERRATA EXTRACTS: IN VITRO AND IN VIVO STUDIES
AIM: To study the hepatoprotective activity of extracts of Boswellia Serrata in paracetamol treated male rats. METHODS: - The dried powder of Boswellia Serrata was extracted successively with different solvent s...
POTENTIAL HYPOGLYCEMIC EFFECT OF ESSENTIAL OIL OF CITRUS RETICULATA IN WISTAR RATS
The essential oil of Citrus reticulata is reported to have antidiabetic activity, but there are no reports on their interaction with commonly used hypoglycemic agent like glibenclamide. The present study was plan...
EFFECT OF POLYMER AND GAS FORMING AGENT ON FLOATING DRUG DELIVERY OF TRAMADOL HYDROCHLORIDE USING RESPONSE SURFACE METHODOLOGY: IN VITRO AND IN VIVO EVALUATION
Tramadol hydrochloride is a synthetic opioid used as a centrally acting analgesic and effective in both experimental and clinical pain. The half-life of the drug is about 5.5 hours and oral dose is 50 to 100 mg every 4...