Effect of telmisartan on blood glucose levels in euglycemic albino rats
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 2
Abstract
Introduction Diabetes is considered primary risk factor for heart disease and comorbidities in older people and in children Due to escalating epidemic diabetes is concerned high profile public health problemMaterials and Methods Swiss albino rats weighing around 150200gms of either sex were randomly selected from the central animal facility Animals were randomly divided into 2 groups six animals in each group A group of 3 rats were kept in individual cages The control was given 05 ml 1 Gum acacia test group was given Telmisartan at the dose of 72mgkgday All the drugs were given orally and for the period of 5 days All rats were fasted overnight before the 5th day On the 5th day glucose 06gmkg body weight was given orally using oral feeding tube and oral glucose tolerance test OGTT was performed Blood was collected by tail snipping method and capillary blood glucose was assessed at 0 60 and 150 minutes using a glucometerResults Fall in capillary blood glucose level was seen in Telmisartan group at alltime intervals when compared to control groupConclusionTelmisartan when given orally for 5 days showed fall in blood glucose level in swiss albino rats Keywords Adipokines Capillary blood glucose Diabetes Euglycemic
Authors and Affiliations
Siddamma Amoghimath, Mrutyunjay Mirje
Keywords
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- EP ID EP478544
- DOI 10.18231/2393-9087.2018.0015
- Views 107
- Downloads 0
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