Effect of three glutamatergic metabotropic receptor ligands on electrically-induced seizures in mice
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
The objective of this study was to determine whether the effect of 3 agonists of glutamatergic metabotropic receptors (mGluRs): ACPT, DCPG, MTPG. ACPT and DCPG (agonists of mGluR III receptors) administered at the dose of 20 mg/kg increased the electroconvulsive threshold in mice. In contrast, MTPG, an agonist of mGluR II and mGluR III receptors, applied at the same dose (20 mg/kg) significantly decreased the threshold, presenting proconvulsant action. This surprising effect may be due to agonistic properties of MTPG towards mGluR II receptors.
Authors and Affiliations
Kinga K. Borowicz
Keywords
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