EFFECTS OF METHANOLIC EXTRACT OF ALPINIA GALANGA FROM MANIPUR (INDIA) ON UTERUS OF OVARIECTOMISED C3H ALBINO MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
Methanolic extract of shade dried rhizome of Alpinia galanga (MAGE) was prepared using Soxhlet apparatus through a minimal of 18 hrs running. Working doses of the MAGE were determined after LD50 study selecting two doses of 200mg/kg Bwt/day and 500mg/kgBwt/day. The ovariectomised mice were randomly allocated into four groups (n=6) viz. vehicle control (1% tween 80), positive control (E2), low dose MAGE (200mg) and high dose MAGE (500mg). After 7 days of oral treatment, animals were sacrificed by cervical dislocation. Sample tissues were carefully collected and weighted using Sartorius balance. Morphological observations revealed that E2¬ treated group showed positive sign of exogenous estrogenic activity by increasing uterine wet weight and relative increase in uterine/body weight ratio. While low dose MAGE treated group shows weak estrogenic activity by increasing uterine wet weight and uterine/body weight, but less pronounced than E2 treated group. The high dose MAGE treated group showed no estrogenic activity rather showed decrease uterine wet weight as well as morphologically constricted uterine horns which clearly suggests anti-estrogenic activity. The present study provides initial evidence towards establishing either estrogen agonistic or antagonistic hormonal property of MAGE in in vivo animal model.
Authors and Affiliations
Rajeevkumar Yungkham , Chandra Jogen
Keywords
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