Efficacy of Annona squamosa (L.) extracts in controlling Diabetes Mellitus in Mice diabetic models
Journal Title: IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB - Year 2018, Vol 4, Issue 6
Abstract
Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies characterized by absolute or relative deficiency of insulin secretion with or without varying degree of insulin resistance. Sedentary life style and obesity are two major epidemiological determinants of diabetes mellitus. The results clearly indicated that the aqueous extract of leaves of Annona squamosa presented significantly lowered body weight (P<0.001) when compared with the normal control (NC) mice in diabetic mice (DC). A significant body weight gain was observed in the treated groups of diabetic mice (DT150 and DT250) as compared to the DC ones. The DT150 and DT250 group showed an increase of 18% and 25% in body weight respectively after 15 days of treatment. Contrary to this DTRGZ group of mice showed an increase of 30% body weight after 15 days of treatment. The DC mice showed significantly (P<0.001) higher level of glucose (+279%) when compared with their normal control counterparts. The diabetic mice of both DT150 and DT250 groups showed a reduction in plasma glucose levels when compared to the DC ones; nevertheless, the reduction was particularly evident in the DT250 mice (-44%; P<0.001). When compared, the glucose levels of the DT250 versus the DC group mice during the four week treatment program, a significant lower value in the first was also found (-45%; P<0.001). Nevertheless, this drop in the glucose levels was more evident in the DT150 mice (-38%) than in the DT250 mice. In contrast to this, DTRGZ group of mice showed almost 67% drop in glucose level after four weeks of treatment program. It is evident that the FINS and HOMA-IR of the diabetic control were much higher than those of the normal control group (P<0.01). When the mice had been administered with vehicle or experimental compounds respectively for 28 days, the FINS levels of A. squamosa extract at 150 mg/kg body weight/day and 250 mg/kg body weight/day doses and rosiglitazone groups were significantly lower as compared to diabetic control (P<0.01), as were the FBG levels (P<0.01). The aqueous leaf extract of A. squamosa at 150 mg/kg body weight/day and 250 mg/kg body weight/day caused lowering of HOMA-IR in treated mice groups as compared to diabetic control (P<0.01). The results clearly indicated that the aqueous extract of Annona squamosa is antidiabetic in nature due to the presence of different types of active phytochemicals.
Authors and Affiliations
Sanjay Kumar Sharma, Moti Lal Gupta, Baidyanath Kumar
Keywords
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- EP ID EP430894
- DOI 10.9790/264X-0406015868.
- Views 130
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