Efficacy of Early N-Acetylcysteine in Rat Killer Paste Poisoning
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2019, Vol 6, Issue 10
Abstract
Introduction: Rat killer paste (yellow phosphorous) is one of the most common forms of poisoning in South India. It causes hepatotoxicity. No specific antidote has been found. Recently, N-acetylcysteine is used as supportive therapy in many cases of acute liver failure. Aim: This study aims to evaluate the effectiveness of early N-acetylcysteine in preventing the rat killer paste poisoning. Methods: Patients who ingested rat killer paste poison and age >12 years were included in the study. Patients having jaundice, liver disease, and age <12 years were excluded from the study. Results: Among 30 patients studied, five patients died, seven patients developed hepatitis, one patient developed acute kidney injury with hepatitis, and one patient developed hyponatremia. Conclusion: Early initiation of N-acetylcysteine had a significant impact in reducing mortality.
Authors and Affiliations
S Saravanan, B Karthik
Keywords
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