Electrolyte abnormalities in chronic heart failure patients on treatment with two different drug regimens
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 5, Issue 3
Abstract
Background: Heart failure is a complex clinical syndrome, impairing the ability of the cardiac ventricles to fill with or eject blood. Drug therapy for Chronic Heart Failure (CHF) is aimed at providing symptomatic relief and has to be continued indefinitely. Currently Angiotensin Converting Enzyme Inhibitor (ACEI), beta blocker and diuretic form the basis of treatment for CHF. These drugs can cause a wide array of electrolyte disturbances which frequently result in potentially dangerous complications. Early identification of these electrolyte disturbances and knowledge of the pathophysiological mechanisms underlying them will help in the effective management of these patients, when complex combinations of drugs are used. Objectives: 1.To estimate the serum sodium and potassium levels in ‘stable’ Chronic Heart Failure (CHF) patients on treatment. 2. To study the impact of Angiotensin Converting Enzyme inhibitors (ACEI), beta blockers and spironolactone with or without furosemide on serum sodium and potassium levels in stable CHF patients receiving the above drugs. Materials and Methods: A cross-sectional study was conducted on 120 stable chronic heart failure patients. In this, 60 patients were under Angiotensin Converting Enzyme inhibitors(ACEI), beta blockers, spironolactone and furosemide, while the other 60 patients were under Angiotensin Converting Enzyme inhibitors(ACEI), beta blockers and spironolactone regimen. Serum creatinine, sodium and potassium levels were analyzed in both the group. Conclusion: Majority of the drugs used in the treatment of CHF cause electrolyte disturbances. Hyponatremia in patients receiving all the four drugs and hyperkalemia in patients receiving only three drugs, was observed in our study.
Authors and Affiliations
A Khadeja Bi, S Suganya, Jnankumar Chaudhuri
Keywords
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