Endocrine-disrupting chemicals in polycystic ovary syndrome: an evidence-based minireview
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2012, Vol 4, Issue 3
Abstract
Polycystic ovary syndrome (PCOS) is a plurifactorial endocrine disorder, affecting 5-10% of women of reproductive age to result in hyperandrogenia, anovulation and infertility, metabolic syndrome and enhanced cardiovascular risk. Animal experiments unraveled that pre- and early postnatal exposure of female offspring to testosterone or bisphenol A (BPA), one synthetic, organic plasticizers component may induce a PCOS-like developmental pattern in adulthood. In contrast to other endocrine-disruption chemicals, information on BPA exposure in biological indicators and wildlife is scarce. On the other hand, the ability of BPA to alter ovarian steroidogenesis has been demonstrated in several cell culture models. In line with that, preliminary clinical studies demonstrated elevated serum and urinary BPA levels in PCOS patients. Nonetheless, a causative role of BPA in PCOS is still under debate and further studies on the topic are warranted.
Authors and Affiliations
Carmen Georgescu, Mihai Șuteu, Bogdan Georgescu
Keywords
Related Articles
- EP ID EP87347
- DOI -
- Views 180
- Downloads 0
Prospective clinical study on cardiotoxicity induced by anthracycline on a sample of 29 patients with breast cancer.
Objective: This study is focused on the evaluation of the early and late cardiotoxic effects of chemotherapy with anthracyclines based on conventional electrocardiography, echocardiography transtoracic, and determination...
Complex therapeutic approach in a child with syndromic morbid obesity and acute heart failur
We report a case of a three years old child, a boy with acute heart failure associated at a rare complex genetic disorders characterized by severe obesity and hypotonia. The treatment consisted of acute phase...
The history and use of optical coherence tomography in ophthalmolog
This paper presents the history and use of optical coherence tomography (OCT) in ophthalmology.
Properties of natural zeolites in benefit of nutrition and health
Due to their remarkable properties, natural zeolites have come to the attention of medicine researchers to find new ways of treating various diseases and ensure an improved supply of mineralsin nutrition. The research re...
Herd problems and occupational zoonoses of Salmonella enterica serovars Typhimurium and Enteritidis infection in diarrheic cattle and buffalo calves in Egypt
This study aimed to investigate Salmonella enterica serovar Typhimurium (ST) and Salmonella enterica serovar Enteritidis (SE) infections of diarrheic calves in bovine dairy herds and their farm workers. Antimicrobial dru...