ENHANCED PERCUTANEOUS PERMEABILITY OF ACYCLOVIR BY DMSO FROM TOPICAL GEL FORMULATION
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2009, Vol 1, Issue 1
Abstract
The aim of this study was to investigate the effect of DMSO on the permeation of acyclovir in the form of topical gel formulations. Different formulations were prepared containing carbopol 934P, acyclovir (1 % w/w) and selected concentration of DMSO (0 to 10% w/w) to evaluate drug content, spreadibility, pH, viscosity, and in-vitro permeation through mouse epidermis and porcine skin. FTIR spectrometry was used to investigate physical state of drug in the gel formulations. The mechanisms of drug permeation were evaluated by FTIR spectrophotometer and histopathological studies. The carbopol 934P gel was found to contain 95.62 to 98.89 % of acyclovir and spreadibility was found in the range of 10.75 to 11.75 g.cm/sec. The pH of all formulations was found near to the skin pH value. The viscosity of the formulations was found inversely proportional with drug permeation. A maximum permeation flux of acyclovir (463.42±36.41µg/cm2.h) through porcine skin was observed with an enhancement ratio of 1.55, when DMSO was incorporated at a concentration of 10%w/w in gel system. The FTIR spectra revealed the absence of drug-polymer interaction. From FTIR spectroscopy and histopathological studies it was evident that the permeation of acyclovir, across mouse and porcine skin, were increased in presence of DMSO which can be attributed to the partial extraction of lipids in the stratum corneum. The results suggest that DMSO may be useful for enhancing the skin permeability of acyclovir from transdermal therapeutic system containing carbopol 934P gel as reservoir.
Authors and Affiliations
Sanjay Dey, Bhaskar Mazumder, J. R. Patel
Keywords
Related Articles
- EP ID EP664876
- DOI 10.25004/IJPSDR.2009.010104
- Views 113
- Downloads 0
Development and Validation of RP-HPLC for Estimation of Neratinib in Bulk and Tablet Dosage Form
An accurate RP-HPLC method developed for the estimation of Neratinib in bulk and tablet dosage form. The method is and validated for parameters linearity, accuracy, suitability, specificity, precession, LOD, LOQ and robu...
COMPARISON OF DIFFERENT GRANULATION TECHNIQUES FOR LACTOSE MONOHYDRATE
The objective of this study was directed to improve the physical and technical properties of poorly flowing and highly cohesive Lactose monohydrate to solve the most important problem that affects tablet manufacture. To...
FORMULATION AND OPTIMIZATION OF NANOSUSPENSION PREPARED BY MEDIA MILLING TECHNIQUE TO ENHANCE THE SOLUBILITY OF ISRADIPINE
Isradipine is a poorly water soluble antihypertensive drug has low bioavailability. The aim of this study was to formulate and characterize isradipine nanosuspension to enhance the solubility of isradipine and thus its b...
GENE THERAPY OF CANCEROUS DISEASES
Gene therapy of cancerous diseases provides new means of curing patients with oncologic illnesses. There are several approaches in treating cancer by gene therapy. Most commonly used methods are: cancer immunogene therap...
ANTIOXIDANT ACTIVITY OF FLAVONOIDS ISOLATED FROM THE FRUITS OF XYLOPIA PARVIFLORA (A. RICH.) BENTH
The present study evaluates the antioxidant activity of the different flavonoids of the fruits of Xylopia parviflora used in Cameroon as spice in common traditional dishes. The fruits were successively extracted with hex...