ENHANCING THE INTESTINAL ABSORPTION OF METFORMIN MOLECULE VIA HPEPT1 TRANSPORTERS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 2
Abstract
Type II diabetes mellitus (DM) is a chronic metabolic disorder with an increasing global prevalence and incidence. It is characterized by raised blood glucose levels as a result of insulin resistance and/ or pancreatic beta-cell failure. Metformin is a widely prescribed anti-hyperglycemic agent used for treatment of type II diabetes mellitus particularly in obese patients. Metformin accumulates in enterocytes during oral absorption with low bioavailability range between 40%-60%. Therefore, new metformin derivatives were synthesized by incorporation of metformin molecule to valine and arginine amino acids with their esters (A4-5) and (B 4-5) respectively via glycolic acid spacer. The chemical structure of the intermediates and the final compounds were confirmed by measuring their melting points, FT-IR spectroscopy and HNMR spectroscopy of the final compounds. Preliminary antidiabetic studies of the final compounds were evaluated by using streptozotocin induced diabetic rat model and it revealed significant anti-hyperglycemic activity of the final compounds compared to metformin.
Authors and Affiliations
Dr. Najwan K. Jubair
Keywords
Related Articles
- EP ID EP617650
- DOI -
- Views 183
- Downloads 0
ROLE OF CLINICAL PHARMACISTS, INTERACTION WITH DOCTORS AND THE BARRIERS FACING THEM IN KHARTOUM STATE PUBLIC HOSPITALS, KHARTOUM, SUDAN, 2013
Clinical Pharmacy is the use of the pharmacist’s skills and knowledge of drugs and therapeutics to improve patient care (pharmaceutical care). Objectives To assess the role of clinical pharmacists (CPs), their interactio...
A NOVEL SYNTHESIS OF CEFIXIME FROM 7-AMINO-3-VINYL CEPHALOSPORANIC ACID (7-AVCA)
The present invention relates to simple and easy process for the preparation of cefixime. 7-amino-3-vinyl cephalosporanic acid (7-AVCA) is reacted with 2-mercapto-1,3-benzothiazolyl-(Z)-2-(3-aminothiazol-4-yl)-2-(methoxy...
A EXTENSIVELY SECOND-HAND DRUGS: TOPICAL AGENTS
The skin & mucosa form the largest organ system in the body. There are many dermatologic condition that affect the skin of the face & perioral areas. Several diseases that are primary to the oral mucosa or systemic disea...
ARTESUNATE RESTORES EXPRESSIVE SPEECH AND IMPROVES COGNITIVE FUNCTION IN A PROFOUNDLY DEAF CHILD WITH DOWN’S SYNDROME FEATURES: LITERATURE REVIEW AND A CASE REPORT
There is a variable penetrance and severity of the resulting pathologies in the chromosomal disorder, John Langdon Down’s syndrome (DS). Down’s syndrome is the commonest human non-inheritable cause of mental disability a...
CONCEPTUAL STUDY OF SHEETAPITTA WITH SPECIAL REFERENCE TO URTICARIA
Ayurveda is the science of life providing guidelines on ideal daily and seasonal routines, diet, behaviour and proper use of senses for healthy and happy life. It suggests health as the balanced and dynamic integration b...