Esophageal and Gastric T-Cell Lymphoma: A Rare Entity
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2012, Vol 1, Issue 1
Abstract
Background: Primary gastrointestinal T-cell lymphomas are extremely rare entity and are much less common than B-Cell lymphomas. Case History: A primary T-cell lymphoma was diagnosed in an octogenarian African American male with a history of diabetes mellitus type-II, remote history of prostate cancer, hypertension, obesity and hyperlipidemia. He had symptoms of dysphagia, early satiety, loss of appetite and loss of weight. He was Helicobacter pylori IgG antibody positive and on treatment. Result of first biopsy during endoscopy showed only heavy lymphoid infiltrate. But, due to high suspicion of malignancy, a second upper gastrointestinal endoscopy and biopsy was performed .This biopsy from the large deep 3cm friable ulcer with nodular base from esophagus was taken which showed atypical lymphoid cells positive for CD3 and CD7 and negative for CD5, CD4, CD8 and CD56. The combination of the histological, immunohistological stain results and the gene rearrangement results confirmed T cell lymphoma. The patient died after 5 months after 5 cycles of chemotherapeutic agents of severe dehydration and complications from sepsis.
Authors and Affiliations
Raja Shekhar R. Sappati Biyyani, Manoj Kumar Bupathi, Amy Soloman, Annette Kyprianou
Keywords
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