Estimation of Blood Glucose as an Indirect Assessment For Attenuation Of Stress Response By Dexmedetomidine Versus Fentanyl Premedication During Laparoscopic Appendectomy: A Clinical Study
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 3
Abstract
Background: Anaesthesia and surgery-induced neuroendocrine stress response can be modulated by appropriate premedication. The present study was done to assess the clinical efficacy of dexmedetomidine versus fentanyl premedication for attenuation of neuroendocrine stress response by analysing the perioperative variation of blood glucose level during Laparoscopic appendectomy under general anaesthesia. Methodology: 40 patients of ASA physical status I or II of either sex, aged between 20-60 yrs scheduled to undergo elective Laparoscopic appendectomy under general anaesthesia were randomly divided by envelope method into one of the 2 groups of 20 patients each (group D and group F). Patients allocated in group D (n = 20) were given IV infusion of dexmedetomidine 1μg/kg in 100 ml normal saline and Group F (n = 20) were given IV infusion of fentanyl 2 μg/kg in 100 ml normal saline over a 15 min period before the induction of general anaesthesia. Serial random blood sugar estimation was done perioperatively. Heart rate and mean arterial pressure were recorded at various time intervals. Results: Our study demonstrated that, there was increment in mean RBS value from the basal value, 30 mins after beginning of surgery, 28% and 31% in Group D and group F respectively, both of which were statistically significant. 10 mins following extubation there was 39% increase from the basal value in group F which was clinically and statistically significant (p <0.001) and 33% increase from the basal value in Group D which was also significant statistically (p <0.001). Conclusion: Both dexmedetomidine and fentanyl premedication attenuated the neuroendocrine stress response of laparoscopic appendectomy under general anaesthesia, as assessed by analysing the variation of blood glucose levels. The dexmedetomidine premedication was better when compared to fentanyl premedication.
Authors and Affiliations
Pramod D
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