The Potential Hypoglycemic Activity of Pinus merkusii Bark Ethanolic Extract in Streptozotocin-Induced Diabetic Rats.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 3
Abstract
In this study, in vivo hypoglycemic activity of Pinus merkusii bark extracts was evaluated against streptozotocin-induced diabetic rats. The rat of male were divided into control group (Rats were given with distilled water); diabetic group (Rats were injected with streptozotocin 65 mg/kg BW i.p), and the treatment group (Rats were injected with streptozotocin 65 mg/kg BW i.p and were given the Pinus merkusii extract 200 mg; 400 mg; 800 mg/kg BW orally). The blood were taken to be measured glucose, insulin level. Furthermore, rats were sacrificed and pancreas tissues were used for the analyzes of MDA. Administration of streptozotocin resulted significantly in increased glucose and MDA the level, and also decrease in the level of insulin were compared with the control group. Administration of the Pinus merkusii extract only 800 mg/kg BW significant decreased the glucose and MDA levels, and also increase in the level of insulin. It could be concluded that, the potential of the Pinus merkusii extract may be useful as a hypoglycemic agent in against streptozotocin-induced diabetic rats.
Authors and Affiliations
Prof. Sri Agus Sudjarwao
Keywords
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