Estimation of Lactate Dehydrogenase Activity in cerebrospinal fluid in different types of meningitis
Journal Title: International journal of Advanced Biological and Biomedical Research - Year 2017, Vol 6, Issue 1
Abstract
Objective: Meningitis is life-threatening condition and examination of the Cerebrospinal fluid (CSF) may not give a precise diagnosis and prognosis of different types of meningitis. Bacterial meningitis is still a very common problem especially in many developing countries. The aims of study are to estimate the importance and significance of Lactate Dehydrogenase (LDH), protein and sugar in CSF of different types of meningitis. Methods: A total of 160 cases, aged between 1 month and 60 years, including patients with bacterial meningitis (n=50), pyogenic meningitis (n=46), viral meningitis (n=24) and a control group (n=40), were analyzed on the basis of data from the initial clinical examinations. Results: Significant increase in LDH level (P<0.001) were observed in the test group when compared to the control group. The LDH activity was significantly elevated in the CSF and serum (p < 0.001) in cases of pyogenic (PM) as well as tuberculosis meningitis (TBM). Bacterial meningitis is more common than non bacterial meningitis. The enzymatic activity of LDH although significantly raised in PM compared to TBM but there was no cutoff level to differentiate them. The LDH level did rise quite significantly in pyogenic meningitis.
Authors and Affiliations
Ranbeer kumar Singh| Department of Microbiology Narayan Medical College and Hospital, Jamuhar, Sasaram, Bihar, Farhan Usmani| Department of Biochemistry, Patna medical college and Hospital, Patna, India, Syed Shahzadul Haque| Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India, Md. Tanweeruddin| Department of Anaesthesiology and Critical Care, ECR, Danapur, Baban Kumar Singh| Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India
Keywords
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- EP ID EP13579
- DOI 10.18869/IJABBR.2017.412
- Views 412
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