Evaluating the association between first trimester screening tests and adverse perinatal outcomes
Journal Title: Journal of Research in Medical and Dental Science - Year 2017, Vol 5, Issue 6
Abstract
Prenatal screening tests are not diagnostic and only show and determine the risk of fetal abnormalities. This study aimed to evaluate the association between the results of double marker test and nuchal translucency (NT) in first trimester with adverse perinatal outcomes (Low-Birth-Weight, Small for Gestational Age, Intrauterine Growth Restriction, Aneuploidy, and fetal abnormalities) in pregnant women. This nested case control study was conducted on two groups of pregnant women. In case group (n=46) the result of double test in first trimester was positive (more than 1.50) and nuchal translucency was also positive (more than 3 mm). In control group (n = 77) the result of double test and nuchal translucency was negative. For each woman, data including demographic data, gestational age, gravidity, parity, number of abortion, weight and height of pregnant women, and the results of double screening test and nuchal translucency were recorded in a check list. For women who had positive test, amniocentesis (in 16 weeks of pregnancy) was performed. Borderline cases were followed using cell free fetal DNA or quadruple screening test. All women were followed during pregnancy until delivery. The prevalence of Down syndrome, intrauterine growth restriction and fetal abnormality in case group was more than the control group and difference was significant statistically (P = .001). Trisomy 18 and 13 were not found in the two groups. In terms of the frequency of spinal cord defects, respiratory distress, SGA, LBW and infant mortality there was no significant difference between the two groups. Conclusion: Our findings showed that adverse perinatal outcomes in screening positive cases were higher. Therefore the double marker test could be helpful in detecting fetal outcomes such as intrauterine growth restriction and fetal structural abnormalities.
Authors and Affiliations
Fariba Seyedoshohadaei, Nasrin Soofizadeh, Masomeh Rezaie, Sirous Hemmatpour, Elnaz Agha Aziziz Kheyavi
Keywords
Related Articles
- EP ID EP306732
- DOI -
- Views 196
- Downloads 0
Distally Based Sural Fasciocutaneous Flap and Cross-leg Method for Soft Tissue Reconstruction of the Distal Leg, Ankle, and Hind Foot Defects
This paper presents the authors’ experience of using cross-leg and direct sural fasciocutaneous flaps for the treatment of various soft tissue defects in the lower limb. All surgeries were performed during 2010-2014. Thi...
The Relationships between SORD -888G>C Gene Polymorphism and Diabetic Retinopathy in a South Sumatran Malay Population
The sorbitol dehydrogenase (SORD) enzyme has 2 promoter regions with polymorphisms at -1214 C>G (rs2055858) and -888 G>C (rs3759890), which have a complete imbalance, related to gene expression in retinal cells of diabet...
Facial and Dental Trauma among Accident Victims (Epidemiology, Diagnosis and Treatment)
Dental and facial injuries may happen in many motorcycle accidents. In most cases, the injured person is referred to a doctor immediately to assess the possible wound. Therefore, control and management of the damaged tee...
Correlation Duration of Oral Steroids Drug Administration by Intraocular Pressure in Patients with Systemic Lupus Erythematosus (SLE) in Dr. Mohammad Hoesin General Hospital Palembang
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease and multisystem organ involvement. SLE patients given treatment are manifold, one of which is with steroids. Long time drug administration depends on the...
Determination of titanium in orthodontic with modified graphene paste electrode and ionic liquid by potentiometric method
Two new potentiometric methods for determination of titanium in pure form and in its pharmaceutical form are developed. In the first method, new modified carbon paste electrode based on(SAPD) as a chemical modifier. The...