EVALUATION OF ANTI-ULCEROGENIC POTENTIAL OF ABUTILON INDICUM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3
Abstract
The present study was undertaken to evaluate the anti-ulcer properties of Abutilon indicum (AI). Ethanolic (AIE) and aqueous extracts (AIA) of AI were studied for their ability to inhibit the gastric lesions in pylorus ligation, aspirin and alcohol induced ulcer models in rats. In addition their effects on pH, wall mucus, total acidity and gastric acid output were recorded. The test drugs in the dose of 200 mg/kg were administered twice daily orally at 10:00 h and 16:00 h respectively for five days for gastro protective studies. Ranitidine was used as reference drug. Ethanolic and aqueous extracts of Abutilon indicum significantly inhibited the gastric lesions induced by pylorus ligation, aspirin and alcohol. The gastric volume and total acidity were found to be significantly reduced while the gastric pH and mucus contents were found to be increased as compared to control group. The present findings suggest that the antiulcer properties of Abutilon indicum may be due to its effect on both offensive and defensive factors. These results support the ethno medical uses of Abutilon indicum in the treatment of ulcer.
Authors and Affiliations
Satish Sharma , Seshasai Sharma , Vipin Saini , Sharmistha Mohapatra
Keywords
Related Articles
- EP ID EP93266
- DOI 10.7897/2230-8407.04350
- Views 112
- Downloads 0
FORMULATION AND EVALUATION OF STAVUDINE LOADED SODIUM ALGINATE BEADS BY IONOTROPIC GELATION METHOD
The objective of the present study was to develop hydrophilic polymer and hydrophobic polymer based novel control release Stavudine beads for achieving the action up to 12 h and to characterize the efficacy and to analyz...
PHYTOCHEMICAL ANALYSIS OF SEEDS OF CERTAIN MEDICINAL PLANTS
Azardiracta indica (Meliaceae), Trigonella foenum-graecum (Fabaceae) and Pongamia pinnata (Fabaceae) are some of the ancient plants of great medicinal value. Physicochemical and phytochemical estimation was carried out o...
PHYTOCHEMICAL INVESTIGATION ON WITHANIA SOMNIFERA ROOT MARC GENERATED IN AYURVEDIC INDUSTRY
Water extraction is a major process in Ayurvedic medicine manufacturing industry. This process involves water extraction of huge quantity of herbs, which culminates in the generation of large amount of marc or herbal res...
IN VITRO ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES EVALUATION OF METHANOLIC EXTRACT OF CAESALPINIA PULCHERRIMA FLOWERS
The current study was conducted to prove ethno medicinal value of the plant, investigating anti-microbial, antioxidant, and total phenolic content of crude methanolic extract of flowers of Caesalpinia pulcherrima. The me...
RIVAROXABAN: AN ORAL DIRECT INHIBITOR OF FACTOR X-A
Venous thrombo embolism (VTE), which includes deep vein thrombosis and pulmonary embolism, is a major cause of morbidity and mortality in patients undergoing major orthopaedic surgery, and routine thrombo prophylaxis has...