Evaluation of antidiabetic and antiinflammatory activity of fatty extract of Caprus hircus milk in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 2
Abstract
Capra hircus(goat) is one of the domesticated animals used for milk, meat and fibre. Milk is one of the essential products in the human diet, rich in nutritive components. Goat's milk has vitamins, minerals, trace elements, electrolytes, enzymes, proteins, and fatty acids that are easily assimilated by the body. The fatty acids present in Caprus hircus milk was revealed to have more beneficial properties to health and used as a traditional medicine for.The present study is aimed to investigate the antidiabetic and anti-inflammatory effect of isopropanol extract of milk of Caprus hircus. The antidiabetic activity was evaluated by measuring blood glucose level in rats treated with isopropanol extract of caprine milk and comparing to normal and streptozotocin (STZ) induced rats. The isopropanol extract of Caprus hircus produced significant changes in the streptazotocin induced diabetic rats by reducing the glucose levels considerably. isopropanol extract treated group(200 mg/kg b.w) showed the mean value of 157.6±3.656 and 117.6±3.839 respectively as compared with a mean value 317.2±4.244 of diabetic control group. The anti-inflammatory activity was assessed by carrageenam induced paw edema model in rats.There was significant reduction (p< 0.01) in paw diameter in the group that received high dose (200 mg/kg b.w) of isopropanol extract of Caprus hircus milk from Mean±SEM of 0.184±0.004 to 0.052±0.003 (71.73%) as compared with the disease control group. The present study concludes that caprine milk extract confirmed promising anti diabetic activity in streptozotocin induced diabetic Wister rats and significant anti- inflammatory properties against carrageenan induced paw edema.
Authors and Affiliations
D. N. Anusha D. N. Anusha
Keywords
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