In silico structure based molecular expression and modeling of PTEN gene for proteus syndrome
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 3
Abstract
Proteus syndrome is a very complex and rare to find in world. It consists asymmetric and disproportionate overgrowth in bones and skins. There are very few cases that have been come in light all over the world such as 1 over 1 million. The drug designing is the inventive process of finding new medications based on the knowledge of a biological target. It also involves the design of small molecules that are complementary in shape and charge to the bimolecular target with which they interact and therefore will bind to it. Proteus syndrome is caused by AKT1 and PTEN genes. The PTEN gene is taken for the modeling and research. It consists 403 amino acids and it acts as a tumor suppressor. Proteus syndrome is not a disease but a disorder. It is related to the PI3K-AKT Signaling Pathway which eventually led to the clinical approaches as their effect. So that, the structure based molecular expression and modeling can be taken to a direction and lead to the mainly drug designing for the welfare of the suffering persons of this syndrome.
Authors and Affiliations
Ayushi Arya
Keywords
Related Articles
- EP ID EP410904
- DOI -
- Views 137
- Downloads 0
The study of prescription pattern in respiratory tract infection diseases in a tertiary care hospital
Introduction A respiratory tract infection is an infection anywhere in the respiratory tract (i.e nose, throat, lungs). The infection can be caused by bacteria, viruses or fungi. Respiratory infections are very common....
Influence of Toddalia asiatica on cardio biomarkers and its protective role against Isoproterenol Induced Myocardial Infarction in Rats
The objective of the study was to evaluate the influence of ethanolic leaf extract of Toddalia asiatica on cardio biomarkers against isoproterenol induced myocardial infarction in rats. The protective activity of Toddal...
A review on essentials of drug interactions
Drug interactions are widely an important source of medication errors. Recently, potentially serious drug-drug interactions among medication errors has achieved significant clinical importance. An interaction is said to...
Beneficial effect of Elaeocarpus ganitrus on MPTP induced parkinson’s disease in mice
Aim of the study: Elaeocarpus ganitrus (Family: Elaeocarpaceae), has shown benefit in the treatment of depression, convulsions and asthma. This study was undertaken to evaluate the antiparkinson effect of E.ganitrus. Mat...
Retrospective study of cutaneous adverse drug reactions reported at adverse drug reaction monitoring centre (AMC) at GMC/GGH, Guntur, Andhra - Pradesh, India
Background One of the most common manifestation of adverse drug reactions is cutaneous adverse drug reaction, which includes skin and it's appendages, mucous membranes, occurring with a wide variation in morphological p...