Influence of Toddalia asiatica on cardio biomarkers and its protective role against Isoproterenol Induced Myocardial Infarction in Rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2018, Vol 7, Issue 1
Abstract
The objective of the study was to evaluate the influence of ethanolic leaf extract of Toddalia asiatica on cardio biomarkers against isoproterenol induced myocardial infarction in rats. The protective activity of Toddalia asiatica was assessed by estimating the cardiac marker enzymes (Creatinine Phosphokinase and Lactate Dehydrogenase) and antioxidants enzymes (superoxide dismutase and Catalase). Thirty male Sprague – Dawley rats were randomly allocated in 5 groups of 6 each. Group I served as control, II to V animals were Isoproterenol (85mg/kg) induced myocardiaol infracted animals, pre treated with the reference control Lipistat (350mg/kg) and ethanolic leaf extract of Toddalia asiatica (200 & 400 mg/kg). All the test drugs were administered orally for 15 days. On 16th day the blood was collected and subjected to the estimation of cardiac marker enzymes. The animals were sacrificed; hearts were homogenized and used for the estimation of antioxidant enzymes. The result showed that, Toddalia asiatica significantly decreased the cardiac marker enzyme and increased the antioxidant enzymes. Toddalia asiatica produced a dose dependent cardioprotective effect against the acute cardiac damage induced by Isoproterenol in rats. From the result it was concluded that, Toddalia asiatica produced cardioprotective activity against isoproterenol induced cardiac damage in rats which was mediated by its antioxidant property.
Authors and Affiliations
Jayakumar Paramasivam
Keywords
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