Evaluation of anxiolytic and hypoglycemic activity of methanolic extract of Ixora cuneifolia in an animal model
Journal Title: Journal of Coastal Life Medicine - Year 2017, Vol 5, Issue 10
Abstract
Objective: To investigate anxiolytic and hypoglycemic activity of Ixora cuneifolia (Family: Rubiaceae) in an experimental animal model. Methods: Anxiolytic test was performed by elevated plus maze (EPM) and hole-board method. Hypoglycemic activity was measured in glucose-loaded Swiss albino mice by glucose tolerance test. Results: The methanol extract of Ixora cuneifolia exhibited dose-dependent and statistically significant (P < 0.05) anxiolytic activity at doses of 200 and 400 mg/kg. Reduction of glucose level was observed with the highest dose 400 mg/kg of the extract in glucose tolerance test. Conclusions: The better anxiolytic and hypoglycemic activities in the present study could be due to the presence of different chemical constituents like alkaloids, flavonoids, saponin, phenols and tannins in this methanolic extract.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP236756
- DOI 10.12980/jclm.5.2017J7-111
- Views 126
- Downloads 0
Impact of Plasmodium falciparum infection on some haematological parameters in a malaria endemic population, Southeastern Nigeria
Objective: To compare changes in some haematological parameters among malaria positive and negative subjects in a malaria endemic community, Southeastern Nigeria. Methods: Haematological parameters of 443 subjects includ...
Effect of some biological factors on the chitin yield of two crustacean species inhabiting the Egyptian waters
Objective: To investigate the chitin yield of two commercial crustacean species that are exploited in the Suez Canal region, the Red Sea crab Charybdis natator (C. natator) and the Mediterranean mantis shrimp Erugosquill...
Sustainable figerling production technique of endangered Labeo calbasu (Hamilton, 1822) based on different protein levels in ponds
Objective: To conduct on sustainable fingerling production technique of endangered Labeo calbasu (Hamilton, 1822) (L. calbasu) based on different protein levels in ponds. Methods: The experiment was carried out under rea...
Intussusception associated with a linear foreign body in a dog: A case report
Intussusception due to linear foreign body obstruction was described in this clinical report in a dog presented with a history of lethargy, anorexia, vomiting and abdominal pain. Diagnosis of intussusception was confirme...
Two case reports of toxocariasis mimicking endophthalmitis in immunosuppresed adults
This a case of 2 immunocompromised patients with a surprising ocular toxocariasis infestation. The first is a 23-year-old girl who is a known case of systemic lupus erythematosus, presenting with both eyes progressive bl...