EVALUATION OF CARDIOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT OF GARCINIA INDICA LINN FRUIT RIND
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
Objective: To evaluate Cardioprotective activity of aqueous extract of Garcinia indica Linn fruit rinds.Methods: Wistar rats were divided into different groups. Two doses 250 mg/kg and 500 mg/kg b.w, p.o of the Garcinia indica fruit rind extract (GIFE) were subjected for the evaluation of Cardioprotective activity against Isoproterenol (ISO) and Ischemia reperfusion injury (IRI) induced myocardial damage in rats. Propranolol (10 mg/kg b.w, p.o) was used as a standard drug. The influence of prophylactic treatment was analysed by quantification of biomarkers and antioxidants, physical parameters and histopathological observations.Results: Both GIFE-250 and GIFE-500 showed significant reduction in CK-MB, CK-NAC, LDH in the extract treated rats when compared with positive control. Both the doses showed increase in SOD and CAT levels. Significant level of percentage recovery in terms of heart rate and developed tension were seen in all treated groups in IRI model. Cardioprotective effect was also confirmed by histopathology of hearts which showed less necrosis in extract treated rats when compared to untreated rats of toxic control group. The results obtained were comparable with that of the standard. Thus investigational finding conclude that, the administration of high dose of GIFE was the most effective in alleviating the abnormal conditions induced by Isoproterenol and Ischemia reperfusion.Conclusion: The present study concluded that Garcinia indica Linn fruit rinds were found to be effective against Isoproterenol (ISO) and Ischemia reperfusion (IR) induced myocardial damage in rats.Keywords: Cardioprotective, Garcinia indica,Ischemia reperfusion injury, Isoproterenol, Propranolol
Authors and Affiliations
Karunakar Hegde, Dhruv Kamlesh Kumar Patel, Keerthi Varma
Keywords
Related Articles
- EP ID EP605636
- DOI -
- Views 80
- Downloads 0
THE ROLE OF HEALTH INFORMATION SYSTEM IN MATERNAL AND CHILD HEALTHCARE SERVICES
Health information system deals with any system that helps in capturing, storing, transmitting, and managing health-related information of an individual or to demonstrate the activities or organizations working within he...
DEVELOPMENT, EVALUATION AND TARGETING OF STAVUDINE LOADED SERUM ALBUMIN POLYMER BASED NANOCARRIERS TO HIV RESERVOIRS
Objective: Stavudine is an antiretroviral drug that is part of the nucleoside reverse transcriptase inhibitor (NRTIs) family, which is used to delay the progression of HIV infection. The present investigation involves th...
OPTIMUM CONDITIONS FOR N-ACETYL GLUCOSAMINE PRODUCTION FROM TIGER SHRIMP (PENAEUS MONODON) SHELL BY SERRATIA MARCESCENS
Objective: The aim of this research was to determine the optimum condition for Serratia marcescens to produce optimum amount of N-acetyl glucosamine using chitin isolated from tiger shrimp (Penaeus monodon) shells.Method...
DEVELOPMENT AND CHARACTERIZATION OF BIOCOMPATIBLE POLYHYDROXY BUTYRATE IMPREGNATED WITH HERBAL PLANTS AGAINST WOUND HEALING ACTIVITY ON IN VIVO ANIMAL MODEL
Objective: The current study is to evaluate the antimicrobial, antioxidant, anti-inflammatory, and in vitro cytotoxicity activities of polyhydroxybutyrate (PHB) and to develop the herbal impregnated PHB cast film for wou...
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF THE AERIAL PARTS OF PHYLLANTHUS RETICULATES AGAINST PARACETAMOL INDUCED HEPATIC DAMAGE IN RATS
ABSTRACTObjective: The present study deals with evaluation of hepatoprotective effect against paracetamol induced hepatitis in rats and in-vitro antioxidantactivity of aerial parts of ethanolic extract (70%) of Phyllanth...