Evaluation of Clinico-Hematological and Biochemical Changes in Dengue Fever at CIMSH Lucknow
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 7
Abstract
Introduction: Among the mosquito borne viral infections. Dengue fever is not only major health problem in Indian subcontinent but it has become a major global health concern. Objective of study was to evaluation of clinico-hematological and biochemical changes in dengue fever at CIMSH Lucknow Material and Methods: Clinically suspected cases of dengue fever, were confirmed by immunological test which consists of dengue NS1 antigen and IgM antibody. during the period from August to December 2016. A total of 100 seropositive dengue cases were correlated with clinical features, hematological, and biochemical findings. The relevant data was analyzed using STAT a software version 2.0 Result: Males were 59 (59%) and females were 41(41%). The age ranged from 18-70 years with mean age of 30.4±11.4 years. Most common clinical features were high grade fever (90%), body ache (90%), purpuric rash (85%), headache (80%), restlessness (80%), Anorexia (70%) and general weakness (68%) (Table 4). The main hematological findings were raised hematocrit (27%) (Table 3), leukopenia (50%), and thrombocytopenia (89%) (Table 2). Alteration in liver function like: rise in SGPT (60%), SGOT (74%), serum alkaline phosphatase (9%) and serum bilirubin in 4% of cases (Table 2). According to WHO criteria 81% patient fall under dengue Fever (DF) category while 15% and 4% patient fall in Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) category (Table1). Conclusion: Fever, body ache, purpuric rashes, headache, restlessness, anorexia and generalized weakness along with leukopenia, thrombocytopenia, raised SGPT, SGOT, hematocrit gives enough clues to test for dengue serology to confirm dengue fever. So early therapeutic measures should be initiated to reduce the morbidity and mortality.
Authors and Affiliations
Mohd. Yaseen, Shamim Ahmad Khan
Keywords
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