Evaluation of Heteropogon contortus (L.) Beauv. Methanolic extract for Mast cell, Cell Membrane and free radical stabilization
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
Methanolic extract of Heteropogon contortus (L.) Beauv was screened for mast cell stabilization (in vitro anti-histaminic) and membrane stabilization (in vitro anti-inflammatory) effects. Extracts was also evaluated for antioxidant effect (DPPH, % RRI of DPPH, reducing power and metal chelation). In addition extract was standardized using chromatographic fingerprinting and spectroscopic quantitation for phytoconstituents contents. HC-ME exhibited good anti-hisatminic effect in by reducing histamine release quantity from C-48/80 induced mast cells destabilization. Stabilizes hypotonic and heat induced destabilized cell membrane. Findings of the above studies helps to reveals that, HC-ME not only exhibit antioxidant activity but also exhibit membrane and mast cell stabilization potential.
Authors and Affiliations
MAHAVIR H. GHANTE, KISHORE P. BHUSARI, NANDKISHORE J. DURAGKAR
Keywords
Related Articles
- EP ID EP223286
- DOI -
- Views 113
- Downloads 0
Evaluation of Lepidium sativum Mucilage as Suspending Agent in Paracetamol Suspension
Mucilages are polysaccharide complexes formed from sugar and uronic acid units. Mucilages form slimy masses in water, are typically heterogeneous in composition. The objectives of present investigation were to evaluate L...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND VELPATASVIR DRUG PRODUCT BY RP-HPLC METHOD
Abstract A novel reversed phase high performance liquid chromatography (RP-HPLC) method has been developed for the estimation of Sofosbuvir and Velpatasvir drug product by liquid chromatography. The chromatographic separ...
Formulation and evaluation of taste masked oral disintegrating tablet of ondansetron hydrochloride
The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. The purpose of this research was to mask the intensely...
DEVELOPMENT OF METOPROLOL TARTRATE PULSATILE DRUG DELIVERY FORMULATION BY PRESS COATED TECHNOLOGY
Abstract Pulsatile drug delivery is novel chronotherapeutic drug delivery system. In the present research work pulsatile drug delivery system of Metoprolol tartrate tablets were formulated and developed by employing comp...
FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE TRANSDERMAL PATCH
Transdermal drug delivery systems (TDDS) are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. In the current research Diltiazem hydrochloride was loaded in transdermal...