Evaluation of Heteropogon contortus (L.) Beauv. Methanolic extract for Mast cell, Cell Membrane and free radical stabilization
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
Methanolic extract of Heteropogon contortus (L.) Beauv was screened for mast cell stabilization (in vitro anti-histaminic) and membrane stabilization (in vitro anti-inflammatory) effects. Extracts was also evaluated for antioxidant effect (DPPH, % RRI of DPPH, reducing power and metal chelation). In addition extract was standardized using chromatographic fingerprinting and spectroscopic quantitation for phytoconstituents contents. HC-ME exhibited good anti-hisatminic effect in by reducing histamine release quantity from C-48/80 induced mast cells destabilization. Stabilizes hypotonic and heat induced destabilized cell membrane. Findings of the above studies helps to reveals that, HC-ME not only exhibit antioxidant activity but also exhibit membrane and mast cell stabilization potential.
Authors and Affiliations
MAHAVIR H. GHANTE, KISHORE P. BHUSARI, NANDKISHORE J. DURAGKAR
Keywords
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