Expression of Human Papilloma Virus in Oral Sub mucous Fibrosis Patients- A PCR Based Assay Study.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 2
Abstract
Oral submucous fibrosis is a chronic disease of oral mucosa characterized by inflammation and progressive fibrosis of the lamina propria and deeper connective tissues, followed by stiffening of oral mucosa resulting in difficulty in opening the mouth.¹ The pathogenesis of OSMF is multifactorial. Epidemiological data indicate that areca nut is the main etiological factor for OSMF. Other etiological factors are chillies, lime, tobacco, nutritional deficiencies, immunological disorders, viruses and collagen disorders.² Human papilloma viruses (HPVs) are small DNA viruses of papillomaviridae that infect various human epithelial tissues exclusively. More than 130 HPV types are identified which are classified into low or high – risk groups according to their potential for oncogenesis.³ Several studies have shown that HPV is associated with increased risk of oral cancer, independent of exposure to tobacco and alcohol. This association is valid for HPV 16 and 18 which are generally considered high-risk types because they have been detected in oral dysplastic lesions and oral cancers. The role of HPV as an etiologic agent in cancer was first recognized in the uterine cervix and is now well established.⁴ The first evidence of HPV in OSCC was shown in 1977, numerous studies have been conducted in supporting the role of HPV as a causative agent for OSCC and premalignant conditions.⁵ There is an increasing evidence of a causal association between high risk HPV types mainly HPV 16/18 and OSMF.⁶ A vast number of studies have been conducted to show the correlation of HPV with oral cancer as an etiologic agent with oncogenic potential but very few studies have been conducted to show the correlation between HPV and OSMF. Although many studies have shown positivity of HPV in oral malignant lesions, only few researchers have compared HPV in normal mucosa and OSMF. The present study was taken up for determining the expression of HPV-16 in normal oral mucosa and OSMF through polymerase chain reaction assay (PCR) technique.
Authors and Affiliations
Juveria Arshi
Keywords
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