FACTORIAL DESIGN BASED OPTIMIZATION AND IN-VITRO – EX-VIVO EVALUATION OF CLOBETASOL LOADED NANO STRUCTURED LIPID CARRIERS
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 9
Abstract
The aim of the present work was to develop and evaluate the potential of nanostructured lipid carriers (NLCs) loaded with Clobetasol-17-propionate (CP) as a new approach for the topical treatment of psoriasis. CP-loaded NLCs were prepared by melt emulsification and ultra-sonication method and optimized using 33 full factorial designs (Design-Expert software 11.0), by using solid lipid (compritol ATO 888) and liquid lipid (oleic acid) and Tween 80 as a surfactant. Drug loaded NLCs were evaluated for various parameters like particle size, surface charge, polydispersity index, entrapment efficiency, surface morphology, thermal analysis, in-vitro drug release through the skin (Franz diffusion cell), drug deposition study and stability. The optimized formulation has a particle size of 91.2 ± 2.37 nm, the zeta potential of -34.7 ± 1.49 mV, polydispersity index of 0.173 ± 0.035 and entrapment efficiency of 85.4 ± 2.89%. Release study demonstrated prolonged CP release from NLCs following Higuchi release kinetics with r2 = 0.9838, while pure CP suspension showed quicker drug release obeying zero-order kinetics with r2 value of 0.9904. Skin permeation study of CP loaded SLNs suspension showed prolonged drug release up to 24 h. The maximum ex-vivo drug deposition was obtained after developing the drug into NLCs (51.23 µg/ml) when compared to the pure drug (18.34 µg/ml). The prepared NLCs based formulation has proved to be a promising carrier system for the treatment of psoriasis.
Authors and Affiliations
V. J. Reddy et al.
Keywords
Related Articles
- EP ID EP627633
- DOI 10.13040/IJPSR.0975-8232.10(9).4374-83
- Views 98
- Downloads 0
FORMULATION AND EVALUATION OF ENTERIC COATED ASPIRIN TABLET BY USING BIOEPOXY RESIN AS COATING MATERIAL
An enteric coating is a polymer barrier applied to oral tablets; it prevents dissolution and disintegration of tablet in the gastric environment. Some drugs like aspirin that have an irritant effect on the GI Track after...
ASSESSING THE EFFECT OF FARTLEK TRAINING ON PERCEIVED WELLNESS OF UNIVERSITY STUDENTS OF SAUDI ARABIA: A RANDOMIZED CONTROLLED TRIAL
Wellness is described as positive health of an individual as indicated by the quality of life and a sense of well-being. This research aimed to assess the effect of supervised fartlek training on Perceived Wellness of Un...
ANTIOXIDANT ACTIVITY OF TWO WILD TEUCRIUM SPECIES FROM MOROCCO
The aim of the present study was to investigate antioxidant activity, total polyphenols and total flavonoids contents of extracts from two Moroccan Teucrium species (Teucrium polium and Teucrium aurum). The Antioxidant a...
SYNTHESIS OF NOVEL 2-PHENYL-1-BENZOFURAN-3(2H)-ONE DERIVATIVES AS NEW LEADS FOR ANTI-CANCER ACTIVITY
Benzofuranone is a bicyclic ring where a benzene ring fused with a furanone. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Bromophenyl acetonitrile was prepared from phenyl aceton...
THE ACTIVITY OF EURYCOMANONE DERIVATIVES ON CANCER CELL LINES
Eurycomanone from the roots of Eurycoma longifolia Jack (ELJ) has been reported to exhibit anticancer activity. Four of ester eurycomanone derivatives: eurycomanone dibutyrate, eurycomanone monovalerate, eurycomanone dim...